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Efficacy of Jawarish Falafali in Siman Mufrit (obesity): A pre-post analytical clinical study.
Abstract
Background & Objectives: Obesity (Siman Mufrit) is characterized by excess adipose tissue mass and increased BMI. Obesity has already reached epidemic proportions. In 2016, 1.9 billion adults worldwide were overweight. Of these over 650 million were obese. About 340 million adolescents (aged 5-19) and 41 million children (age < 5) were overweight or obese. NFHS-4 (2015-16) reported that obesity in India doubled in the last decade. Obesity is strongly associated with various cardiovascular, metabolic, and systemic disorders. In Unani literature, Siman Mufrit is categorized as a balghami disease. Management includes dieto-therapy, pharmacotherapy and regimenal therapy. Treatment modalities should have har-yabis effect. Also, mudir, mushil, moarriq, musakhkhin, mulattif, muhallil and mufattit drugs are useful. Consequently, Jawarish Falafali, a Unani compound formulation was selected for study to substantiate its efficacy in Siman Mufrit (obesity) on scientific parameters.
Methods: The study-design was single-arm pre-and post-analysis clinical trial with 30 subjects aged between 18-60 years and having BMI between 30-40 kg/m2. The test drug Jawarish Falafali was given orally 5 gm OD for 60 days. Follow-up was done fortnightly. Efficacy was assessed by change in bodyweight, BMI, waist circumference, waist-hip ratio and lipid profile. The outcome was analyzed using appropriate statistical methods.
Results: A significant decrease (p<0.001) was observed in all primary outcome measures i.e. body weight, BMI, waist circumference, waist-hip ratio after treatment. Also, a significant reduction in lipid profile (TC, TG and LDL) except HDL (p=0.083) was detected.
Interpretation & Conclusion: This study revealed that the test drug effectively reduced obesity.
Keywords
References
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DOI: https://doi.org/10.37591/joayush.v9i3.2182
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