ALADIN and its Protein Interactions with the Nucleoproteins: An Insilico Analysis

Abstract

The nuclear pore complex (NPCs) are big, protein complexes made up of multiple units that traverse the nuclear envelope (NE), establishing a discerning channel between the cytoplasm and nucleus for the nucleocytoplasmic transport. It has different roles in cellular processes, like cell-cycle progression, control of gene expression, and signal transduction. NPC is a vast and complex structure, compiled from almost 30 proteins, termed nucleoporins. Earlier studies have shown that each nucleoporins has an exclusive role in controlling NPC function and the nucleocytoplasmic transport of proteins and RNAs. ALADIN also referred to as adracalin is a nucleoporin is associated with a genetically heritable human disease known as Triple A syndrome. But many mutant ALADIN studies have showed that defect is functional rather than structural, so further suggesting an intricate protein interaction network among several hundred individual components of this ordered assembly of huge complex. In this study, insilico tools have been used to predict the protein-protein interactions of ALADIN protein with other nucleoporins.

Keywords: Nucleoporin, mutant, signal transduction, protein interactions, WD-repeats

Cite this Article

A. Sharma, M. Khurana, R. Kaur. Aladin and its Protein Interactions with the Nucleoproteins: An Insilico Analysis. Research & Reviews: Journal of Computational Biology. 2018; 7(1):       28–31p.