Lipid Peroxidation in Postoperative Cases of Breast Carcinoma (Grade III)

Abstract

Breast cancer represents significant problem in the world. Oxidative modification of lipids is catalyzed by reactive oxygen species (ROS) which is known as lipid peroxidation (LPO); this changes the fluidity, permeability of membrane, cellular metabolic functions and causes derangement. Malondialdehyde (MDA) is a major end product and an index of LPO which crosslinks DNA, protein and nucleotides on the same and opposite strands. There are reports that LPO increased in preoperative cases of breast carcinoma, but post-surgery studies have not been done; so this study has been designed to observe LPO in postoperative cases at three months. For this 60 breast cancer cases of grade III (FNAC diagnosed) and 30 normal healthy controls were taken. There was significant decrease in LPO in postoperative cases, but decrease was not comparable with normal values which may lead to recurrence of carcinoma. Steps should be taken to reduce LPO in postoperative cases as factor leading to oxidative stress is one of the major causes of carcinogenesis.

Keywords: Malondialdehyde (MDA), cancer, postoperative, antioxidants, lipids

Cite this Article

Verma P. Lipid Peroxidation in Postoperative Cases of Breast Carcinoma (Grade III). Research & Reviews: A Journal of Health Professions. 2018; 8(1): 16–22p.