Role of Nitric Oxide Synthase in Platelets of Breast Carcinoma

Abstract

Breast cancer is the leading problem of the world. Free radicals have unpaired electron which can be neutralised by human body for maintaining health, these free radicals are toxic, highly unstable and very reactive. Antioxidants and free radical scavengers protect cells from toxic effects in order to maintain redox state of the cell. Nitric oxide is one of the important free radicals synthesized from nitric oxide synthase. It has been found in previous studies that there was significant increase in nitric oxide in platelets in pre-operative cases of breast carcinoma compared to post-operative and normal healthy controls; therefore, this study has been designed to study levels of nitric oxide synthase in platelets. It has been found that there was significant increase in nitric oxide synthase in platelets in pre-operative cases of breast carcinoma when compared with normal healthy controls and post-operative cases. Therefore, it can be said that steps should be taken to reduce nitric oxide levels, or in other ways, by reducing production of nitric oxide synthase can further decrease production of nitric oxide which is said to be too important biomolecule in carcinogenesis.

Keywords: Breast carcinoma, nitric oxide, nitric oxide synthase, platelets

Cite this Article

Priyanka Verma. Role of Nitric Oxide Synthase in Platelets of Breast Carcinoma. Research & Reviews: A Journal of Health Professions. 2019; 9(1): 36–39P.