Clinical Significance of Immune Cells and T-cell Subsets in Lung Cancer

Abstract

Objectives: The aim of the study was to determine the clinical usefulness of pretreatment hematological parameters including neutrophils, lymphocytes, monocytes and immune T-cell subsets as well as calculated coefficients such as neutrophils-to-lymphocytes ratio(NLR),monocytes-to-lymphocytes ratio(MLR) and platelets-to-lymphocyte ratio(PLR)in patients with lung cancer. Materials and Methods: A total of 102 patients with lung cancer were prospectively analyzed. T-cell subsets were assessed by flow cytometry method. Peripheral blood was collected from 25 healthy donors as control. The data were analyzed using SPSS software and p-value less than < 0.05 was considered statistically significant. Results: In comparison to healthy controls, neutrophils (P=0.0001), absolute neutrophils count (P=0.001), absolute monocyte count (P=0.0001), NLR (P=0.055), MLR (P=0.005) and PLR (P=0.047) was significantly higher while lymphocytes (P=0.0001) was significantly lower in lung cancer patient. Also, CD3+ T-cells (P=0.001), γδTCR (P=0.011), absolute T-cell count (P=0.0001), absolute helper T-cell count (P=0.0001) and absolute cytotoxic T-cell count (P=0.029) was found significantly lower in lung cancer patients. Conclusion: The present study observed neutrophilia, lymphocytopenia, and immune suppression reflect an imbalance in the immune response and contribute to lung carcinogenesis.

Keywords: lung cancer, immune T cells, inflammatory markers, flow cytometry 

Cite this Article

Yadav DK, Modi H, Vora H. Clinical Significance of Immune Cells and T-cell Subsets in Lung Cancer. Research & Reviews: A Journal of Immunology. 2019; 9(2): 14–29p.