Subclinical Significant High Serum Immunoglobulin E Response to 20 Allergens: Age and Gender Based Study

Abstract

Background: Antigen-immunoglobulin E (IgE) reaction is an example of immediate allergic reactions. High serum IgE levels were reported in many diseases that linked to the multiple allergens. Objectives: This study aimed to measure the serum IgE against 20 allergens in patients who had a previous history of allergy due to unidentified precipitating factors. Methods: This retrospective study was conducted at the Al Zahraa Consultant Center for Allergy and Asthma that located in the west of Baghdad, Iraq. The data of a small sample of patients who attended the Center were randomly collected using randomized tables. The collecting data included the age, gender, and levels of immunoglobulin E (IgE) that mediated allergic reactions against 20 allergens related to the food, drugs, and environmental resources. Immunoglobulin E was measured by using an Enzyme-Linked Immuno Sorbent Assay (ELISA) technology. Results: There were non-significant differences between male and female groups concerning the frequency of patients who reacted with significant high serum IgE against 20 allergens. The frequency of male patients that reacted to the 10 environmental allergens is significantly higher than the corresponding frequency of female (68.1% versus 54.9%. p=0.045). Cross-reactions were significantly observed between food and drug allergens in females compared with males (17.6% versus 6%, p=0.007). Conclusions: Significant high serum IgE levels against multiple allergens related to food, drugs, fungus, mites and grass are detected in the subclinical state. Food-Drug cross-reactions are significantly observed in female compared with the male gender.

Keywords: allergens, drug, environmental, food, Serum immunoglobulin E

Cite this Article

Huda Ghassan Hameed, Ihab Ayad Ahmed, Marwan S.M. Al-Nimer. Subclinical Significant High Serum Immunoglobulin E Response to 20 Allergens: Age and Gender Based Study. Research & Reviews: A Journal of Immunology. 2019; 9(3): 1–6p.