Recent Advancement in Understanding the Aetiopathogenesis of Psoriasis: A Review

Abstract

Psoriasis is an immune-mediated inflammatory skin disease with periods of recurrence and remission. Various researches have globally explored the aetiopathogenesis of psoriasis but still it is not crystal clear. Abundant evidence suggest that dysregulation of immune cells in the skin, particularly keratinocytes, T cells, dendritic cells, natural killer cells, neutrophils, and macrophages play a vital role in the development of psoriasis. The combined effects of these cells explain most of the clinical features of psoriasis such as the hyperproliferation of keratinocytes, increased neovascularisation and skin inflammation. Thus understanding the immunological role of these cells in the disease process, this review, mainly focuses on how these cells are activated and involved in the disease pathogenesis.

Keywords: Psoriasis, aetiopathology, keratinocytes, cytokines, hyperproliferation, Inflammation

Cite this Article
Masarat Fatima, Mohd. Aleemuddin Quamri, Mansoor A. Siddiqi. Recent Advancement in Understanding the Aetiopathogenesis of Psoriasis: A Review. Research & Reviews: A Journal of Immunology. 2017; 7(2): 9–21p.