A Study of Lipid Profile in Hypertensive Patients

Abstract

Hypertension is a non-communicable disease which is commonly prevalent in elderly population. Hypertension often coexists with an aberrant lipid profile and has been a pandemic globally, irrespective of the development of the country or community. Public awareness about the role of hyperlipidemia in decreasing the morbidity plays a pivotal role. The objective of this study was to examine the serum lipid patterns of hypertensive patients. This prospective study was carried out in the population of Khammam, Andhra Pradesh, during February 2013 and August 2013. 200 patients with hypertension in the age-range of 40–80 years are the study subjects while 400 age- and sex-matched individuals without hypertension are taken as control. 5 mL of blood was collected from each subject as well as controls after overnight fasting (12 h) by venipuncture. Serum was separated within 1 h and standard methods were followed for biochemical studies. Among the 200 patients studied, 172 were males and 28 females. The results of this study indicate a clear elevation of all the lipid parameters except for HDL. There is a 10–15% increase in triglycerides, S. Cholesterol, LDL, TC/HDL and LDL/HDL values. HDL values are decreased and significantly in females at lower age compared to males. Triglycerides too are elevated in females earlier as compared to males. The lipid profile in hypertensive patients is momentously altered as compared to that of controls. Total cholesterol, LDL cholesterol, triglycerides, VLDL, TC/HDL and LDL/HDL ratios were significantly elevated in patients with hypertension (p < 0.05). HDL is significantly reduced in hypertensive subjects (p < 0.05).

Keywords: Hyperlipidemia, hypertension, LDL, triglycerides, VLDL