Gastroesophageal Reflux Disease and the Role of Prokinetics Along with PPIS

Abstract

Gastroesophageal reflux disease (GERD) is often confused with functional dyspepsia as dyspepsia symptom commonly coexist with heartburn and some patients with functional dyspepsia respond to proton pump inhibitor (PPI) therapy. Up to 25–50% of patients with functional dyspepsia defined according to Rome III criteria can have abnormal esophageal acid exposure. Functional dyspepsia presents of one or more of the following symptoms: Postprandial fullness, early satiation, epigastric pain or burning, and no evidence of structural disease. Symptoms last for at least three months with the onset at least six months before diagnosis. Based on the prominent symptoms, it can be categorized into postprandial distress syndrome and epigastric pain syndrome.

Keywords: Gastroesophageal reflux, diaphragm, proton pump inhibitor, refractory patients

Cite this Article

Arya MK. Gastroesophageal Reflux Disease and the Role of Prokinetics Along with PPIS. Research and Reviews: Journal of Medicine. 2016; 6(2): 12–14p.