Experimental Study on the Effect of Combination of Two Ginseng-Containing Prescriptions of Koryo Herbal Medicines and Fluconazole in Systemic Candidiasis Mouse Model

Abstract

We evaluated the efficacy of two Ginseng-containing prescriptions of Koryo herbal medicines combined with fluconazole (FLC) against systemic candidiasis, using experimental mouse model. The results showed that combined with FLC, treatment of mice with Sa-Gun-Za-Tang or Sip-Zon-Dae-Bo-Tang significantly increased the survival rates and decreased the number of viable Candida albicans cells in the kidneys compared with treating animals with FLC alone(P<0.01 for both comparisons). Compared with untreated controls, treatment of mice with FLC alone did not increase the number of leukocytes significantly (P>0.05), but with FLC+Sa-Gun-Za-Tang or FLC+Sip-Zon-Dae-Bo-Tang combination significantly increased (P<0.01 for both comparisons) the number of leukocytes. FLC+Sa-Mul-Tang has no potent activity against systemic candidiasis both in terms of improved survival and the number of leukocytes and reduction in organ burden in a murine model (P>0.05).

Keywords: Fluconazole (FLC), herbal medicine, systemic candidiasis, Sip-Zon-Dae-Bo-Tang, Sa-Gun-Za-Tang

Cite this Article

Gum-Ryon Jang, Ryo-Hyon Won, Ye-Rim Ri. Experimental Study on the Effect of Combination of Two Ginseng-Containing Prescriptions of Koryo Herbal Medicines and Fluconazole in Systemic Candidiasis Mouse Model. Research & Reviews: A Journal of Medicine. 2020; 10(1): 24–28p.