A Case of Low-Grade Fibromyxoid Sarcoma: A Rare Soft Tissue Sarcoma

Abstract

Sarcomas are heterogeneous group of tumours that can occur throughout the body. Approximately two third of soft tissue sarcomas (STS) arises in the extremities. These rare tumours accounts for less than 1% cancers in adults. Treatment algorithm for STS depends on tumour stage, site and histology. A 28-year-male patient presented with complaint of swelling over the right anterior aspect of leg since past six months. He had a history of injury over the same area 10 years back and was healed with scar. History of excision was three times within past six months. On examination, 6´7 cm swelling was present in right leg protruding, bleeds on touch, tender and local lymphadenopathy. Edge biopsy was done which showed haematoma. Magnetic resonance imaging (MRI) showed features suggestive of osteosarcoma after which excision biopsy was done and histopathologically, it was reported as low-grade fibromyxoid sarcoma-stage PT2bNxMx. After which wide local excision was done and patient was followed up. Multimodality treatment, including surgical resection, radiation therapy and in selected cases chemotherapy has been applied to patients with locally advanced, high-grade sarcomas. Overall 5 year survival rate for patients with all stages of STS is 50–60%. The most common site of metastases is in the lung and occurs within three years. Doxorubicin-based regimen has been the mainstay of treatment for past two decades; however, it is clear now that the specific histological subtypes have increased sensitivity to specific drugs.

Keywords: Sarcoma, fibromyxoid, fibromyxoid sarcoma

Cite this Article

Singhal N, Joshi CJ, Hanumanthappa MS. A Case of Low-Grade Fibromyxoid Sarcoma: A Rare Soft Tissue Sarcoma. Research & Reviews: Journal of Surgery. 2018; 7(1): 1–4p.