Differential Response by Rotenone on Human Trabecular Meshwork and HeLa Cell Lines

Abstract

Cellular response towards a particular stress condition is dependent on a number of factors including genetic makeup, microenvironmental factors, nutrient availability etc. Cells under same stress condition respond differentially and may exhibit pro-apoptotic or anti-apoptotic behavior. Two quite different cell lines—the cancerous cells of HeLa and the Human Trabecular Meshwork (HTM) cell line with very different microenvironmental requirements behave very differently towards oxidative insult due to rotenone. Study of their differential behavior revealed more susceptibility of HeLa cells in comparison to HTM cells. This clearly supports the therapeutic utility of rotenone against cancerous growth.   

Keywords: rotenone, oxidative stress, cancerous cells of HeLa, human trabecular meshwork cell line, cell behavior

Cite this Article

Maurya N, Agarwal NR, Ghosh I. Differential Response by Rotenone on Human Trabecular Meshwork and HeLa Cell Lines. Research and Reviews: Journal of Toxicology (RRJoT). 2015; 5(2): 14–22p.