Cadmium and Apoptosis: A Molecular Approach

Authors

  • S. Milton Prabu Assistant professor (SG) Department do Zoology, Guindy campus, University of Madras, Chennai
  • K. Shagirtha Department of Biochemistry, St. Joseph’s College, Cuddalore, Tamil Nadu, India

DOI:

https://doi.org/10.37591/rrjot.v6i1.1324

Abstract

 

Apoptosis, also known as programmed cell death is a highly regulated and fundamental process found in all multicellular organisms. It is not only implicated in regulatory mechanisms of cells, but has been attributed to a number of diseases, like inflammation, malignancy, autoimmunity and neuro-degeneration. A variability of pollutants can persuade apoptosis. Oncogenic transition metals like cadmium, promote apoptosis alongside DNA base modifications, strand breaks and rearrangements. Generation of reactive oxygen species, accumulation of Ca2+, upregulation of caspase-3, downregulation of bcl-2,and deficiency of p-53 lead to the Cadmium (Cd) induced apoptosis. Metallothionein expression determines the choice between apoptosis and necrosis in Cd-induced toxicity. Thus, disorders of apoptosis may play a critical role in some of the most debilitating metal-induced afflictions including hepato-toxicity, renal toxicity, neuro-toxicity, autoimmunity and carcinogenesis. An understanding of Cd-induced apoptosis will be obliging in the development of precautionary molecular approach.

 

Keywords: Metals, cadmium, apoptosis, cell proliferation, carcinogenicity

Cite this Article

K. Shagirtha, S. Miltonprabu. Cadmium and Apoptosis: A Molecular Approach. Research and Reviews: A Journal of Toxicology. 2016; 6(1): 8–17p.

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Published

2019-04-09

Issue

Vol. 6 No. 1 (2016)

Section

Review Article

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