Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study

Abstract

Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds are having capacity to protects against various xenobiotics induced oxidative stress mediated diseases such as focal cerebral ischemia, lung inflammation, intracerebral hemorrhage, ischemia and reperfusion induced acute cardiac, hepatic, renal failure, and cancer etc. Sulforaphane is an indirect antioxidant compound is able to induce/activate numerous cytoprotective proteins, including antioxidant enzymes, through the Nrf2/ARE pathway. Because, it poses the powerful electrophiles, attributable to the central carbon atom of the -N= C= S group, which reacts readily with sulfur- nitrogen- and oxygen-based respective antioxidant genes such as heme oxygenase-1, NAD(P)H: quinone oxidoreductase, glutathione-S-transferase, gamma-glutamyl cysteine ligase, and glutathione reductase and induced Nrf2 gene for Phase II enzymes. In conclusion, sulforaphane is a promising antioxidant agent that is effective to attenuate oxidative stress and tissue/cell damage in different in-vivo and in-vitro experimental animals.

Keywords: Sulforaphane, Oxidative stress, rats, liver, kidney, heart, ROS

Cite this Article

Thangapandiyan S, Ramesh M, Miltonprabu S et al. Protective role of Sulforaphane against multiorgan toxicity in rats: An In-vivo and In-vitro review study. Research & Reviews: A Journal of Toxicology. 2018; 8(1): 1–8p.