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Use of Dashamoola in Cervical Spondylosis: Past and Present Perspective

Ashutosh Kumar Pathak, H. H Awasthi, Ajai Kr. Pandey

Abstract


Cervical spondylosis is one of the most common disorders of the cervical spine. It is caused by degenerative changes in the vertebrae and intervertebral discs that occur because of constant improper stress on the cervical spine due to abnormal posture, injury, ageing, rheumatoid disease etc. In conventional system of medicine, a number of factors are responsible for the development of signs and symptoms of cervical spondylosis such as osteophyte (bony growth), narrowed spinal canal present since birth, degeneration of the intervertebral discs, changes in the spinal cord and nerves due to insufficient blood supply. The medical management options include use of analgesics for pain, anticonvulsants, or antidepressants for radicular pain, steroids to reduce inflammation around neural structures, and muscle relaxants. However, the adverse effects that they produce are the limitations in their use. Physical therapy is useful to strengthen neck muscles and supporting ligaments, and traction can help alleviate the nerve compression that occurs with foraminal stenosis. Many medicinal preparations are commonly used for the treatment of pain in alternative medicine. One such commonly used Ayurvedic preparation is Dashamoola, a combination of the roots of ten plants, a standard Ayurvedic remedy for the treatment of pain. In literature of Ayurveda it is said to have Tridosha shamaka and specially Vata shamaka properties along with it is considered as Shothahara, which can be correlated as anti inflammatory properties; Shvasahara–relieves breathing problems and Ama pacana-nullify Ama like reactive species, which may be called as antioxidant or free radical scavenging property. Accordingly, it is indicated for the management of variety of disorders, which is caused by vitiation of Tridosha and preferably in the disorders caused by vitiation of Vata dosha. It is mainly prescribed in shvasa (dyspnea), jvara (hyper pyrexia), sirahshula (cephalgia), tandra (malaise), anaha (flatulence in abdomen) and parsvashula (flank pain) and also indicated in shotha i.e. in inflammatory conditions. It is frequently used as internal medication as well as external medication in form of svedana for cervical spondylosis, which is may be attributed to its shothhara, vatashamana, and amapachana activity. The recent studies showed analgesic, anti-inflammatory along with free radical scavenging property of dashamoola, which justifies its use in cervical spondylosis.


Keywords


dashamoola, spondylosis, analgesic, anti-inflammatory, free radical scavenging

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References


Clark CR, Benzel EC, Currier BL, et al. The Cervical Spine. 4th Edn. The Cervical Spine Research Society Editorial Committee. Philadelphia, PA: Lippincott Williams and Wilkins, 2005.

Garfin SR. Cervical Degenerative Disorders: Etiology, Presentation, and Imaging Studies. Instr Course Lect. 2000; 49: 335–8p.

al-Mefty O, Harkey HL, Marawi I, et al. Experimental Chronic Compressive Cervical Myelopathy. J Neurosurg. Oct 1993; 79(4): 550–61p.

Shedid D, Benzel EC. Cervical Spondylosis Anatomy: Pathophysiology and Biomechanics. Neurosurgery. 2007; 60: S7–13p.

Bohlman HH, Emery SE. The Pathophysiology of Cervical Spondylosis and Myelopathy. Spine. 1988; 13: 843–6p.

McCormack BM, Weinstein PR. Cervical Spondylosis. An Update. West J Med. Jul–Aug 1996; 165(1–2): 43–51p.

Heller JG. The Syndromes of Degenerative Cervical Disease. Orthop Clin North Am. Jul 1992; 23(3): 381–94p.

Q. Liu et al. Fullerol Nanoparticles Suppress Inflammatory Response and Adipogenesis of Vertebral Bone Marrow Stromal Cells—A Potential Novel Treatment for Intervertebral Disc Degeneration. Spine J. 2013; 13(11): 1571–1580p.

Mittal Sandhya, Rao Nidhi, Sudhanshu, et al. Determination of Natural Compounds in Dashmool Extracts by Thin Layer Chromatography and High–Pressure Liquid Chromatography. Int. J. Res. Ayur. Pharm. 2012; 3(6): 814–817p.

Ramana G, Reddy ChS, Rao ChV. In-vitro and in-vivo Anti-Oxidant Activity of Ficus racemosa Linn. Fruit Extract and Aegle marmelos Root and Leaf Extracts. Journal of Pharmacy Research. 2011; 4(7): 2078–81p.

Siddique NA, Mujeeb M, Najmi AK, et al. Evaluation of Antioxidant Activity, Quantitative Estimation of Phenols and Flavonoids in Different Parts of Aegle marmelos. Afr. J. Plant Sci. 2010; 4(1): 001–5p.

Singh N, Jain DA, Rao ChV, et al. Antioxidant and Phytochemical Study of Aegle marmelos Fruits and Root. Int J Pharm Sci Rev Res. 2012; 16(1): 96–100p.

Gokani RH, Lahiri SK, Santani DD, et al. Evaluation of Anti-Inflammatory and Antioxidant Activity of Premna integrifolia Root. J Complement Integr Med. 2011; 8(1).

Shukla S, Saluja AK, Pandya SS. Antioxidant Activity and Free Radical Scavenging Potential of Gmelina arborea Linn. Pharmacologyonline. 2009; 1: 1035–43p.

Audipudi AV, Chakicherla BVS. Antioxidative and Antimicrobial Activity of Methanol and Chloroform Extracts of Gmelina arborea Roxb. Int J Biotechnol Biochem. 2010; 6(1): 139–144p.

N’gaman KCC, Mamyrbekova-bekro JA, Bekro YA. Effect of Flavonoids of Gmelina arborea Roxb. (Verbenaceae) from Côte d'Ivoire on the Antioxidant Activity and Osmotic Stability of Erythrocytes. Journal of Applied Biosciences. 2011; 39: 2626–34p.

Rathi A, Rao ChV, Ravishankar B, et al. Anti-Inflammatory and Antinociceptive Activity of the Water Decoction Desmodium gangeticum. J Ethnopharmacol. 2004; 95(2–3): 259–63p.

Sagar MK, Upadhyay A, Kalpana, et al. Evaluation of Antinociceptive and Anti-Inflammatory Properties of Desmodium gangeticum (L.) in Experimental Animal Models. Arch Appl Sci Res. 2010; 2(4): 33–43p.

Kirubha SV, Jegadeesan M, Kavimani S. Evaluation of Antioxidant Property of Desmodium gangeticum and Pseudarthria viscida Roots. T. J Chem Pharm Res. 2013; 5(1): 367–70p.

Srivats S, Ramakrishnan G, Paddikkala J, et al. An in vivo and in vitro Analysis of Free Radical Scavenging Potential Possessed by Desmodium gangeticum Chloroform Root Extract: Interpretation by Gsms. Pak J Pharm Sci. 2012; 25(1): 27–34p.

Zaveri M, Jain S. Gastroprotective Effects of Root Bark of Oroxylum indicum, Vent. J Nat Remedies. 2007; 7/2: 269–77p.

Mishra SL, Sinhamahapatra PK, Nayak A, et al. In vitro Antioxidant Potential of Different Parts of Oroxylum indicum: A Comparative Study. Indian J Pharma Sci. 2010; 72(2): 267–9p.

Zaveri M, Dhru B. In-vitro Antioxidant Potential of Stem and Root Bark of oroxylum indicum. Journal of Global Pharma Technology (JGPT). 2010; 2(8): 42–8p.

Ng TB, Liu F, Wang ZT. Antioxidant Activity of Natural Products from Plants. Life Sci. 2000; 68: 709–23p.

Ahirrao P, Jagtap A, Shirke S, et al. Comparative Assessment of Anti-Inflammatory Potential of Asparagus racemosus and Uraria picta. Proc Life Sci. 2007: PC108.

Ghildiyal S, Gautam MK, Joshi VK, et al. Anti-Inflammatory Activity of Two Classical Formulations of Laghupanchamula in Rats. Journal of Ayurveda & Integrative Medicine (J-AIM). 2013; 4(1): 23–7p.

Dawane JS, Pandit V, Borole K. Experimental Evaluation of Antipyretic Activity of Aqueous Extract of Dashamula. Spatula DD. 2012; 2(1): 17–21p.

Singh RS, Ahmad M, Wafai ZA, et al. Anti-Inflammatory Effects of Dashmula, an Ayurvedic Preparation, versus Diclofenac in Animal Models. J Chem Pharm Res. 2011; 3(6): 882–8p.

Nagarkar Bhagyashri, Jagtap Suresh, Narkhede Aarti et al. Different Ayurvedic Dosage Forms of Dashamoola Possess Varied Anti-Inflammatory Activity. World Journal of Pharmacy and Pharmaceutical Sciences. 2013; 2(5): 3118–3136p.


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