Munzijate Balgham with Interpretation to Their Mechanism of Action in Stroke Rehabilitation: A Review

Authors

  • S Javed Ali Programme Assistant, Department of Moalejat, Ajmal Khan Tibbiya College, Aligarh Muslim University, Aligarh
  • Abdul Nasir Ansari

Keywords:

Munzijate Balgham, neuro-rehabilitation, hemiplegia, Falij

Abstract

The basic line of treatment of Falij Balghami is use of Munzijate Balgham followed by Mushilat and Muqawwiyat. Munzijat is the group of drugs which suitably modify the consistency of morbid Akhlat to make them able to evacuate from the tissues, vessels and interstitial spaces. They act either by liquefying the consistency of Ghaleez Akhlat, or by thickening the Raqeeq Akhlat. Nuzj occurs over a period of time which varies according to the affection of different morbid Akhlat. Conventional treatment of stroke entails the use of antiplatelet, anticoagulant, and fibrinolytic drugs which resemble the mechanism of action imparted by Munzije Balgham drugs endowed with properties such as Tahleel, Taqtee, and Talteef. Neuroplasticity and neuroprotection are considered the fundamental theories behind the long-term neuro-rehabilitation in patients of stroke. Recent studies have proven the effect of a few herbal drugs used as Munzijate Balgham in enhancing neuroplasticity and neuroprotection. Studies on human subjects suggest effectiveness of Munzijate Balgham in improving motor power, gait rehabilitation and alleviation of spasticity.  This paper aims at reviewing some common Munzijate Balgham with reference to their mechanism of action in Stroke Rehabilitation.

References

Greenberg DA, Aminoff MJ, Simon RP. Clinical Neurology, 5th Edn. McGraw-Hill/Appleton & Lange. 2002.

Colledge NR, Walker BR, Ralston SH. Davidson’s Principles and of Practice of Medicine, 21st Edn. Edinburgh: Churchill Livingstone. 2010.

Duncan PW. Stroke disability. Physical Therapy. 1994; 74(5): 30–39p.

Ropper AH, Brown RH. Adam and Victor’s Principal of Neurology, 8th Edn. New York: McGraw-Hill. 2005.

Tabri Ahaim. Al Mualajatul Buqratiya. New Delhi: CCRUM; 1994.

Maseehi Bsiiy. Kitabul Mia’h. New Delhi: CCRUM. 2008.

Ibne Sina Aahia. Al Qanoon Fit Tib. New Delhi: Idara Kitabush Shifa. 2010.

Arzani A. Tibbe Akbar. New Delhi: Idara Kitabush Shifa.

Majoosi AIA. Kaamilus Sana’ah. New Delhi: CCRUM. 2010.

Razi Amiz. Kitabul Hawi. New Delhi: CCRUM. 1997.

Colledge NR, Walker BR, Ralston SH. Davidson’s Principles and of Practice of Medicine, 21st Edn. Edinburgh: Churchill Livingstone. 2010.

Longo DL, Kasper DL, Jameson JL, et al. Harrison’s Principles of Internal Medicine, 18th Edn. New York: McGraw-Hill Companies. 2012.

Ibne Rushd AWM. Kitabul Kulliyat, 1st Edn. New Delhi: CCRUM. 1987.

Khan MA. Al-Ikseer. New Delhi: Ejaz Publishing House. 2003.

Rampuri NG. Khazainul Advia. New Delhi: Idara Kitabush Shifa.

Maghribi ASII. Kitabul Fat’h Fit Tadawi Min Jamee’i Sunoofil Amraz Wash Shakawi, 1st Edn. Delhi: AYUSH. 2007.

Lee MK, Kim JM. The effect of action observational training on arm function in people with stroke. Phys Ther Kor. 2011; 18: 27–34p.

Ravichandra V, Devi A, Adiga S, et al. Evaluation of the effect of Glycyrrhiza glabra Linn root extract on spatial learning and passive avoidance response in rats. Indian Drugs. 2007; 44(3): 214–19p.

Ambawade S, Kasture V, Kasture SB. Anxiolytic activity of Glycyrrhiza glabra Linn. Journal of Natural Remedies. 2001 July; 1(2): 130–34p.

Muralidharan P, Balamurugan G, Babu V. Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract on hypoxic rats. Bangaladesh Journal of Pharmacology. 2009; 4: 60–64p.

Dhingra D, Parle M, Kulkarni SK. Memory enhancing activity of Glycyrrhiza glabra in mice. Journal of Ethnopharmacology. 2004 January 15; 91: 361–65p.

Yu XQ, Xye CC, Zhou ZW, et al. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sciences. 2008 January 2;.82(1-2): 68–78p.

Tognolini M, Ballabeni V, Bertoni S, Bruni R, et al. Protective effect of Foeniculum vulgareessential oil and anethole in an experimental model of thrombosis. Pharmacological Research. 2007 September;.56(3):.254–60p.

Abdul Ghani AS, Amin R. The vascular action of aqueous extract of Foeniculum vulgare leaves. Journal of Ethnopharmacology. 1998 December;.24(2–3): 213–18p.

Jabeen Q, Aziz N, Afzal Z, et al. Tha spasmogenic and spasmolytic activities of Lavandula stoechas are mediated through muscarinic receptor stimulation and calcium channel blockade. International Journal of Pharmacology. 2007; 3(1): 60–67p.

Gilani AH, Aziz N, Khan MA, et al. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas. Journal of Ethnopharmacology. 2000 July; 71(1-2): 161–67p.

Lis-Balchin M, Hart S. Studies on the node of action of the essential oil of lavender. Phytother Res. 1999 September; 13(6): 540–42p.

Karimzadeh F, Hosseini M, Mangeng D, et al. Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. Complementary and Alternative Medicine. 2010; 12(76): 1–9p.

Tirapelli CR, Andrade CRd, Adriano OC, et al. Antispasmodic and relaxant effects of the hydroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. Journal of Ethnopharmacology. 2007; 110: 23–29p.

Ko FN, Huang TF, Teng CM. Vasodialatory action mechanism of apigenin isolatedfrom Apium graiolence in rat thoracic aorta. Biochemica et Biophysica Acta. 1991 November 14; 115(1): 69–74p.

Riaz N et al. Lipoxygenase inhibiting and antioxidant oligostilbene and. Phytochemistry. 2004;.65: 1129–35p

Ghayur M, Gilani A, Rasheed H, et al. Cardiovascular and airway relaxant activities of peony root extract. Can J Physiol Pharmacol. 2008 November;.86(11):.793–803p.

Khan T, Ahmad M. Spasmolytic and spasmogenic activities of crude extract and subsequent fractions of Paeonia emodi. Pharmazie. 2007 June; 62(6): 476–77p.

Gilani AH, Bashir S, Khan A. Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders. Journal of Ethnopharmacology 2007; 114: 393–99p.

Gresham GE. Stroke outcome research. Stroke. 1986; 17: 358–62p.

Heddings AA, Friel KM, Plautz EJ, et al. Factors contributing to motor impairment and recovery after stroke. Neurorehabil. and Neural Repair. 2000; 14: 301–10p.

Xu Ying, Zhang Chong, Ogle O William. The serotonergic system and neuroplasticity are implicated in the effect of phytochemicals on mood and cognitive disorders. Recent Advances in Theories and Practice of Chinese Medicine. 2012; 291–312p.

Bahr M. Neuroprotection-Models, Mechanisms and Therapies. Gottingen: WILEY-VCH Verlag GmbH & Co. KGaA,Weinheim. 2004.

http://users.fmrib.ox.ac.uk/~heidi/thesis/Section 2.pdf. (Cited on 7.1.12.)

Munshi GN. Makhzanul Mufaradat wa Murakabat (Khawasul Adwia), 2nd Edn. New Delhi: CCRUM Ministry of health and Family Welfare, Govt. of India. 2007.

Stroemer RP, Kent TA, Hulsebosch CE. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats. Stroke. 1995; 26: 2135–44p.

Jones TA, Schallert T. Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res. 1992; 581: 156–60p.

Ahmed A, Ansari AN, Ali SJ, Mohd Y. Efficacy of Munzij Wa Mushil-E-Balgham (poly herbal formulations) and massage with Roghan-E-Malkangani in Falij Nisfi (hemiplegia): A randomised controlled clinical trial. Int J Pharm Sci Res. 2015; 6(1): 453–58p.

Yasir M, Ansari AN, Ahmad A, et al. Evaluation of efficacy of Unani regimen in the management of post stroke spasticity, an open observational study. International Research Journal of Medical Sciences 2013; 1(11): 29–34p.

Ali SJ. Efficacy of Munzij and Mushile Balgham and Inkebab with Advia Harrah in rehabilitation of hemiplegic gait in patients of stroke. Dissertation RGUHS. 2014.

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Published

2015-09-10

Issue

Vol. 4 No. 3 (2015)

Section

Review Article

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