

Effect of Virechana Karma, Ketaki-Rasonadi Brimhana-Sneha and Amritadi Ghanavati in Asthikshaya w.s.r. Osteoporosis
Abstract
It is estimated that worldwide, osteoporosis causes more than 8.9 million fractures annually. Long-term use of modern medication of osteoporosis are generally associated with adverse effects like deep vein thrombosis, pulmonary embolism, endometrial cancer, ulcers of esophagus, upper GI irritation, irregular heartbeat and thromboembolic disease. As such, no direct reference of osteoporosis is available in Ayurveda but similar condition is described under different diseases like Asthikshaya, Asthimajjagata Vata. The proper nourishment of any Dhatu depends upon proper functioning of Agni, Srotas and Vata. Ayurveda advises for the correction of basic causative factor. Panchakarma treatment due to its Shodhana effect improves Agni. Virechana Karma, one among the Panchakarma is specific to eliminate the vitiated Pitta, which in turn improves the Agni. Asthikshaya is due to increased Vata; hence Snehana with Taila (oleation) is one of the best treatments for the correction of increased Vata; hence in this study Brimhana-Snehapana with Ketaki-Rasonadi Taila was done. And further, for the nourishment of Dhatu in general and Asthi Dhatun, in particular Rasayana drugs like Amrita, Shatavari, etc. were used as Amritadi Ghanavati. Thus present study has been conducted on 15 patients to evaluate the therapeutic effect of Virechana Karma, Ketaki-Rasonadi Taila-Brimhana-Sneha and Amritadi Ghanavatiin Asthikshaya w.s.r. osteoporosis. The results have been analyzed statistically. Virechana Karma with Brimhana-Sneha and Amritadi Ghanavati are highly effective in osteoporosis (on BMD) which was statistically extremely significant (P .0001).
Keywords
References
Melton LJ, Chrischilles EA, Cooper C, et al. How Many Women have Osteoporosis? J Bone Miner Res. 1992; 7: 1005–1010p.
Riggs BL, Melton LJ III. Involutional Osteoporosis. N Engl J Med. 1986; 314: 1676–86p.
Johnell O, Kanis JA. An Estimate of the Worldwide Prevalence and Disability Associated with Osteoporotic Fractures. Osteoporos Int. 2006; 17: 1726p.
Agnivesha. Charaka Samhita. Revised by Maharshi Charaka and Dradhavala. Ayurveda Dipika. Commentries of Shrimatt Chakrapanidutta, Edited and Revised by Kaviraja Shree Narendranath Sengupta and Kaviraja Shree Balaichandra Sengupta. Fifth Part. 3rd Edn. Sutra Sthana 17/67. Chaukambha Orientalia; 2009; 345p.
Ibidem. Chikitsa Sthana. 28/33: 782p.
Grodstein F, Stamfer MJ, Goldhaber SZ, et al. Prospective Study of Exogenous Hormones and Risk of Pulmonary Embolism in Women. Lancet. 1996; 348: 983–87p.
Fisher B, Costantino JP, Redmond CK, et al. Endometrial Cancer in Tamoxifen- Treated Breast Cancer Patients: Finding from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. Natl Cancer Inst. 1994; 86: 527–37p.
Ibidem. Sutra Sthana. 25/40: 469p.
Ibidem. Cikitsa Sthana. 28/75: 791.
Ibidem. Cikitsa Sthana. 28/181: 807.
Bhavamishara Commented by Chunaker KC. Pandey GS, editor. Bhaprakash Nighantu. Varansi: Chaukhambha Bharti Academy; 2013. Dhanya Varga. 64: 638p.
Arjmandi BH, Birnbaum R, Goyal NV, et al. Bone-Sparing Effect of Soy Protein in Ovarian Hormone-Deficient Rats is Related to its Isoflavone Content. J Am Clin Nutr. 1998; 68: 1364–1368p.
Boulbaroud S, Mesfioui A, Arfaoui A, et al. Preventive Effects of Flaxseed and Sesame Oil on Bone Loss in Ovariectomized Rats. J Pak Biol Sci. 2008; 11: 1696–1701p. doi: 10.3923/pjbs.2008.1696.1701.
Sowmya M, Jeyarani T, Indrani D. Effect of Replacement of Fat with Sesame Oil and Additives on Rheological, Microstructural, Quality Characteristics and Fatty Acid Profile of Cakes. Food Hydrocoll. 2009; 23: 1827–1836p. doi: 10.1016/j.foodhyd.2009.02.008.
Chen Z, Bassford T, Green SB, et al. Postmenopausal Hormone Therapy and Body Composition: A Substudy of the Estrogen Plus Progestin Trial of the Women’s Health Initiative. J Am Clin Nutr. 2005; 82: 651–656p.
Fernandez N, Renedo M, Garcia-Rodriguez C, et al. Activation of Monocytic Cells through Fc Receptors Induces the Expression of Macrophage-Inflammatory Protein (MIP)-1alpha, MIP-beta, and RANTES. J Immunol. 2002; 169: 3321–3328p.
Ibidem. Haritkyadi Varga. 221–223: 127p.
Mukherjee M, Das AS, Mitra S, et al. Prevention of Bone Loss by Oil Extract of Garlic (Allium sativum Linn.) in an Ovariectomized Rat Model of Osteoporosis. Phytother Res. 2004; 18: 389–394p.
Ibidem. Guduchayadi Varga. 144: 251p.
http://www.thehealthierlife.co.uk/ article/3220/osteoporosis.html.
Ibidem. Cikitsa Sthana. 1/8: 5p.
Ibidem. Guduchayadi Varga. 8–9: 257p.
Kapur P, Jarry H, Wuttke W, et al. Evaluation of the Antiosteoporotic Potential of Tinosporacordifolia in Female Rats. The European Menopause Journal. 2008; 59: 229–338p.
Pendse VK. et al. Ind Drugs. 1981; 14.
Gupta SS, Verma SLL, Garg VP. Anti-Diabetic Effect of T. cordifolia. Part I: Effect on Fasting Blood Level, Glucose Tolerance and Adrenaline Induced Hyperglycemia. Indian J Med Res. 1967; 55: 733–745p.
Ibidem. Haritkyadi Varga. 146: 62p.
Ashawat MS, Shailandra S, Swarnlata S. In vitro antioxidant activity of extract of Centellaasiatica, Punicagranatum, Glycyrrnizaglebralinn and Areca catechu. Res Journal of Medicinal Plant. 2007; 1(1): 13–16p.
Ibidem. Guduchayadi Vrga. 186–187: 378p.
Jasmine Ritesh Gujarathi. Minimizing Risk of Postmenopausal Osteoporosis through Shatavari: A Clinical Study. 2013; 2(1): 260–265p.
Ibdem. Guduchayadi Varga. 226–227: 403p.
Shirwaikar A, Khan S, Malini S. Antiosteoporotic Effect of Ethanol Extract of Cissusquadrangularis Linn. On Ovariectomized Rat. J Ethnopharmacol. 2003; 89: 245–50p.
Udupa KN, Prasad G. Biomechanical and Calcium-45 Studies on the Effect of Cissusquadrangularis in Fracture Repair. Indian J Med Res. 1964; 52: 480–7p.
Parisuthiman D, Singhatanadgit W, Dechatiwongse T, et al. Cissusquadrangularis Extract Enhances Biomineralization through Up-Regulation of MAPK-Dependent Alkaline Phosphatase Activity in Osteoblasts. In vitro Cell Dev Biol Anim. 2009; 45: 194–200p.
Aswar Urmila M, Mohan V, Bodhankar Subhash L. Antiosteoporotic Activity of Phytoestrogen-Rich Fraction Separated from Ethanol Extract of Aerial Parts of Cissusquadrangularis in Ovariectomized Rats. Indian J Pharmacol. 2012; 44(3): 345–350p.
Ibidem. Haritkyadi Varga. 93–95: 36p.
Ibidem. Haritkyadi Varga, 49–50: 14p.
Srivastava KC, Mustafa T. Ginger (Zingiberofficinale) in Rheumatism and Musculoskeletal Disorders. Med Hyp. 1992; 39: 342–348p
Refbacks
- There are currently no refbacks.