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Standardization of Rakta-Akika Bhasma and Pisthi: An Ayurvedic Formulation

Parth B. Chandak, Nirali K. Shah, Bharti Umretia, Darshan Parmar

Abstract


Background: Standardization of the classically prepared medicines is a must apart from other organoleptic tests as mentioned in the ancient text. Rakta Akika Bhasma (RAB) and Pishti (RAP) is a traditional Ayurvedic preparation for Hridaroga (Cardiac disease), Shiroroga (headache due to vitiated Dosha), Kasa (cough), Raktaja Vikara (bleeding disorders) and many more. Aim: The present research work was conducted to analyze raw and processed Rakta Akika Bhasma and Pishti for quality assessment using classical and advanced sophisticated techniques. Method: Physicochemical parameters such as loss on drying, total Ash, acid insoluble Ash, water soluble Ash, pH value and sophisticated testing techniques such as X-ray diffraction (XRD), Scanning Electron Microscope (SEM), Energy dispersive X-ray analysis (EDAX) and Particle Size Analysis (PSA) were carried out for the samples of Ashodhita Rakta Akika (ARA), Shodhita Rakta Akika (SRA), Rakta Akika Bhasma (RAB) and Rakta Akika Pishti (RAP). Result: XRD suggested that all the samples are silicon dioxide (low quartz) and highly decreased particles size observed from SEM-EDAX study revealed that ARA and SRA contain Si, Fe and O while RAB and RAP contain Si, Al, O, Fe, Ca and the other elements. Mg is only found in RAB and K in RAB and RAP. PSA analysis revealed that RAB (272.1±19.92 nm) and RAP (42.73±2.309 nm) are having nano ranges particles. Conclusion: The present study of two samples is standardized by using modern sophisticated techniques like XRD, SEM-EDAX and PSA analysis which help to generate the quality assessment and standardization of such important medicine.

Keywords


Rakta Akika Bhasma, Rakta Akika Pishti, quality assessment, standardization

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References


Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. P.67.

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.17

Ayurvedic Pharmacopoeia of India. Part II, Volume III. Government of India, Ministry of Health and Family Welfare. New Delhi: Department of AYUSH; 2008; 4.

Nathusinhji KG. Ayurveda Bhavana Rasatantrasara and Siddhaprayoga Sangraha Prathama khanda. 27th Edn. Varanasi: 2018; 175.

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.9

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.18

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.102

Anonymous. The Ayurvedic Pharmacopoeia of India, Part I, Volume VII. Government of India, Ministry of Health and Family Welfare. New Delhi: Department of AYUSH; 2008; 3.

Geology (2022 Jun 26). Mohs hardness scale. [Online]. Retrieved August 4, 2023, from https://geology.com/minerals/mohs-hardness-scale.shtml.

Mahmut MAT. (2023). Agate. [Online]. Geology science. Retrieved August 4, 2023, from https://geologyscience.com/minerals/silicates-minerals/agate/?amp.

Clarke G. Refractive index chart of gemstones—What does it mean and how do I use it? Gemselect.com. GemSelect; (2007). [Online] Available from: https://www.gemselect.com/gem-info/refractive-index.php

Gérard Barmarin. Luminescence, fluorescence and phosphorescence of minerals. Fluomin.org.(2023). [Online] Available from: https://www.fluomin.org/uk/fiche.php?id=229

Anonymous. The Ayurvedic Pharmacopoeia of India, Part II, Volume I, Appendix 1 to 7. Government of India, Ministry of Health and Family Welfare. New Delhi: Department of AYUSH; 2008; 14.

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.13

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.14

Nathusinhji KG. Rasatantrasara and Siddhaprayoga Sangraha: Prathama Khanda. 27th edn. Varanasi: Ayurveda Bhavana; 2018. p.15

Ayurvedic Pharmacopoeia of India. Part II, Volume III. Government of India, Ministry of Health and Family Welfare. New Delhi: Department of AYUSH; 2008; 198.

Anonymous. The Ayurvedic Pharmacopoeia of India, Part I, Volume II. Government of India, Ministry of Health and Family Welfare. New Delhi: Department of AYUSH; 2008; 95.

Siyavula. (2022 Oct 6). Reactions in aqueous solution. [Online]. Retrieved August 4, 2023, from https://www.siyavula.com/read/science/grade-10/reactions-in-aqueous-solution/18-reactions-in aqueous-solution-04.

Vagbhata S, Tripathi ID. Rasaratna Samuchachaya with Rasprabha Hindi Commentary. Reprint Edn. Varanasi: Chaukhambha Publications; 2013; 90.

Vagbhata S, Tripathi ID. Rasaratna Samuchachaya with Rasprabha Hindi Commentary. Reprint edn. Varanasi: Chaukhambha Publications; 2013. p. 91.

Madhava AS, Sharma GS, Sharma S. Ayurveda Prakasa with Artavidyotini and Arthaprakasini Sanskrit and Hindi Commentaries. Reprint Edn. Varanasi: Chaukhambha Bharati Academy; 2016;28.

Clementina Dilim Igwebike-Ossi. X-Ray Techniques. Failure Analysis and Prevention. Tech; Dec 2017

Murdande Sharad B, Pikal Michael J, Shanker Ravi M, Bogner Robin H. Solubility advantage of amorphous pharmaceuticals, Part 3: Is maximum solubility advantage experimentally attainable and sustainable? J Pharm Sci. Oct 2011; 100(10): 4349–4356.

University of Cambridge. (2022). Crystallinity in polymers. [Online]. Retrieved from https://www.doitpoms.ac.uk/tlplib/polymerbasics/crystallinity.php

Jagadeesh Babu N, Ashwini Nangia. Solubility Advantage of amorphous drugs and pharmaceutical cocrystals. Cryst Growth Des. 2011; 11(7): 2662–2679.

Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arab J Chem. 2019; 12(7): 908–931.

Wadekar MP, Rode CV, Bendale YN, Patil KR, Gaikwad AB, Prabhune AA. Effect of calcination cycles on the preparation of tin oxide based traditional drug: studies on its formation and characterization. J Pharm Biomed Anal. 2006; 41(4): 1473–8. https://doi.org/10.1016/j.jpba.2006.03.032

Rasavagbhata S, Kulkarni DA. Rasa Ratna Samucchaya, with Vijnanbodhini Hindi Trans. and commentary by Prof. Dattatreya Anant Kulkarni. (Ch.8, Ver. 27). Reprint Edn. New Delhi: Meharchand Lachhmandas Publications; 2007; 121.

Emamverdian A, Ding Y, Mokhberdoran F, Xie Y, Zheng X, Wang Y. Silicon dioxide nanoparticles improve plant growth by enhancing antioxidant enzyme capacity in bamboo (Pleioblastus pygmaeus) under lead toxicity. Trees. 2020; 34: 469–48.

ScienceDirect. (2023). Scanning electron microscopy. [Online]. Retrieved from https://www. sciencedirect.com/topics/earth-and-planetary-sciences/scanning-electron-microscopy

Koga D, Kusumi S, Shibata M, Watanable T. Applications of scanning electron microscopy using secondary and backscattered electron signals in neural structure. Front. Neuroanat. 2021; 15: 759804. DOI: 10.3389/fnana.2021.759804

University of California, Irvine. (2022). Malvern Zetasizer ZS DLS user manual. [Online]. Retrieved from https://www.chem.uci.edu/~dmitryf/manuals/Malvern%20Zetasizer%20ZS%20 DLS%20user%20 manual.

Apsara Wijenayake, et al. The Role of Herbometallic Preparations in Traditional Medicine - A Review on Mica Drug Processing and Pharmaceutical Applications. J Ethnopharmacol. 2014 Jul; 155(2): 1029–45. DOI:10.1016/j.jep.2014.06.051.




DOI: https://doi.org/10.37591/rrjoasyn.v10i2.3292

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