Development of vaccine against Helicobacter pylori using Bioinformatics approaches

Abstract

Helicobacter pylori (H. pylori) are a widespread kind of bacteria which flourish in the digestive tract and have a propensity to damage the stomach lining. The microbe infects around 60% of the adults globally. H. pylori infections are responsible for most of stomach and small intestine ulcers. Using Bioinformatics approaches, we have identified certain proteins that possess the resistance, essentiality and virulence factors for this pathogen. Computational tools and servers were used for the identification of MHC class I, II and B cell epitopes. The set of chosen epitopes were also filtered as per their immunogenic and toxicity potentials. Designed vaccine construct was docked against multiple HLA targets employing virtual modeling. Therefore the designated vaccine constructs may be developed to control the infection caused by H. pylori.