Molecular Evolution of Virulence Genes of Coronavirus: A Computational Study

Authors

  • Gyanendra kumar Gupta AFFILATED
  • Gagan devi

Keywords:

Corona virus, Covid 19, Corona viridae, RNA, SARA-CoV, MERS-CoV, RdRP.

Abstract

Corona Virus i.e., Covid 19 is consider as highly pathogenic and transmissible, which is responsible for emerging scenario of current pandemic disease. The family of this virus Coronaviridae, which affect respiratory system of human along with animal, and It is belived to be originated from bat. The homology of covid 19 is mix of SARA-CoV and MERS-CoV. The Single-stranded positive genomic RNA, which is coated by nucleocapsid protein is present in corona virus. The phenomenon of host radiation is influence by mutation of its any gene, such as HA, N, RdRP and So in case of COVID-19. In this article an attempt is made to study its genealogies based on differential gamma distribution rates, which were used for the analysis of null and alternate hypothesis. This study shows that RdRP gene had the fastest rate evolution followed by HA gene.

Author Biography

  • Gyanendra kumar Gupta, AFFILATED
    PHYSIOLOGY

References

Alam, I., Kamau, A.A., Kulmanov, M., Jaremko, Ł., Arold, S.T., Pain, A., et al., 2020. Functional pangenome analysis shows key features of e protein are preserved in sars and sars-cov-2. Front. Cell. Infect. Microbiol. 10, 405.

Bailey, T.L., Boden, M., Buske, F.A., Frith, M., Grant, C.E., Clementi, L., Noble, W.S., 2009. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res. 37 (suppl_2), W202–W208.

Banerjee, A., Santra, D., Maiti, S., 2020. Energetics based epitope screening in SARS CoV- 2 (COVID 19) spike glycoprotein by Immuno-informatic analysis aiming to a suitable vaccine development. BioRxiv.

Brian, D.A., Baric, R.S., 2005. Coronavirus genome structure and replication. Coronavirus Replication and Reverse Genetics, pp. 1–30.

Corman, V.M., Muth, D., Niemeyer, D., Drosten, C., 2018. Hosts and sources of endemic human coronaviruses. In: Advances in Virus Research, Vol. 100. Academic Press, pp. 163–188.

Cortegiani, A., Ingoglia, G., Ippolito, M., Giarratano, A., Einav, S., 2020. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J. Crit. Care.

Elfiky, A.A., 2020. SARS-CoV-2 RNA dependent RNA polymerase (RdRP) targeting: an in silico perspective. J. Biomol. Struct. Dyn. 1–9.

Ghinai, I., McPherson, T.D., Hunter, J.C., Kirking, H.L., Christiansen, D., Joshi, K., Fricchione, M.J., 2020. First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA. Lancet.

Gorbalenya, A.E., Enjuanes, L., Ziebuhr, J., Snijder, E.J., 2006. Nidovirales: evolving the largest RNA virus genome. Virus Res. 117 (1), 17–37.

Kahn, J.S., McIntosh, K., 2005. History and recent advances in coronavirus discovery. Pediatr. Infect. Dis. J. 24 (11), S223–S227.

Downloads

Published

2022-03-12

Issue

Vol. 10 No. 2 (2021)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.