The use of Genetics and Proteomics in the Finding of Therapeutic Targets

Abstract

Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials will help you learn and apply the two strategies for discovering new gene therapy medication targets. Drug discovery and development are critical to humanity's well-being and the pharmaceutical industry's long-term viability. Because of the Human Genome Project's completion, using chemical biology methodologies to discover therapeutic leads has become a generally acknowledged path. Chemical biology mostly solves biological problems by identifying ligands for well-defined therapeutic targets or searching for newly identified targets for pharmacologically active small compounds. It's a useful tool for figuring out how these small molecules interact with their targets, as well as their involvement in signaling, molecular recognition, and cell functions. As a result of developments in functional genomics, a growing number of new therapeutic targets have been identified and validated, leading to the discovery of multiple active small compounds through a variety of high-throughput screening activities. We highlight certain chemical biology applications in the context of drug discovery in this review.