Is Tissue Platelet Count an Important Diagnostic Tool for Oral Cancer?

Authors

  • Sandhya Tamgadge Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, India
  • Avinash Tamgadge Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, India
  • Evie Satheesan Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, India
  • Shashi Bhushan Dodal Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, India
  • Asif Iqbal Dr. D. Y. Patil Dental College and Hospital, Nerul, Navi Mumbai, India

DOI:

https://doi.org/10.37591/rrjod.v5i1.1026

Abstract

 

Metastasis is the main cause of cancer-related deaths and a major challenge in today’s cancer management. Although many new therapies against malignant tumors have been developed over the last few years, the prognosis of most malignancies remains unfavorable, once metastatic spread has occurred. There are plethora of studies indicating that the interaction of tumor cells with platelets within the bloodstream is essential during this early phase of metastasis. Ironically, however, in the past century, the wide range of platelet contributions to health and disease has stimulated intense study of platelet function such as anti-platelet therapy. There are various laboratory tests available for platelet analysis, which include study of growth factors, immunohistochemistry, blood platelet count, etc., but platelet count in biopsy tissue itself has not been explored in malignancy. Therefore, this review article highlights the importance of tissue platelet count using simple histochemical stain in various oral precancers and cancers which have not been explored yet.

 

Keywords: Oral cancer, platelet analysis, biopsy tissue, metastasis


Downloads

Published

2019-03-28

Issue

Vol. 5 No. 1 (2014)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.