Open Access Open Access  Restricted Access Subscription or Fee Access

Therepi: A Replenishable Implanted Epicardial Reservoir

Seema Chawla, Chetna Sharma

Abstract


The healthcare technology has been advancing at such a high pace which was not expected some years back. This paper is an attempt to introduce not so known, still existing and in-development phase, techniques which can revolutionize the healthcare industry in different domains. The recent technological development in coronary therapies have shown a great promise in restoring the abnormalities present in the heart after the patient experiences heart attack; certain amount of scarring in the myocardial still remains prominent. The removal of scarring along with restoration of complete function of the cardiac could extinguish the series of events which resulted in heart failure. It is believed that the vehicles for biomaterial delivery increases the cellular retention of the cardiac with the increase in rate of survival in comparison to other therapies, thus opening new paradigms for future studies using this kind of delivery vehicle. Moreover, the deliveries of cell show that multiple administrations are therapeutically more effective in comparison to single doses in case of heart failure animal models. Any system offering multiple administrations without the requirement of multiple surgeries so far has not yet come into existence which is the main driving force to develop the design for the “Therepi”.

 

Keywords: Therepi, heart attack, paradigm

Cite this Article

Sharma C, Chawla S. Therepi: A Replenishable Implanted Epicardial Reservoir. Research & Reviews: A Journal of Health Professions. 2019; 9(2): 12–16p.


Full Text:

PDF

References


O’Neill, H. S. et al. Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac feld and future perspectives. Adv. Mater. 28, 5648–5661 (2016).

Hastings, C. L. et al. Drug and cell delivery for cardiac regeneration. Adv. Drug Deliv. Rev. 84, 85–106 (2015).

Jung, D. W. & Williams, D. R. Reawakening atlas: chemical approaches to repair or replace dysfunctional musculature. ACS Chem. Biol. 7,1773–1790 (2012).

. Plowright, A. T., Engkvist, O., Gill, A., Knerr, L. & Wang, Q. D. Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents. Angew. Chem. Int. Ed. 53, 4056–4075 (2014).

Segers, V. F. M. & Lee, R. T. Protein therapeutics for cardiac regeneration after myocardial infarction. J. Cardiovasc. Transl. Res. 3, 469–477 (2010).

Segers, V. F. M. et al. Local delivery of protease-resistant stromal cell derived

factor-1 for stem cell recruitment afer myocardial infarction. Circulation 116,1683–1692 (2007).

Ziegler, M. et al. Te bispecifc SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation 125,685–696 (2012).

Urbanek, K. et al. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ. Res. 97, 663–673 (2005).

Jabbour, A. et al. Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses. Eur. J. Heart Fail. 13,83–92 (2011).

Torella, D. et al. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. 94,514–524 (2004).

Hsueh, Y. C., Wu, J. M., Yu, C. K., Wu, K. K. & Hsieh, P. C. Prostaglandin E2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells. EMBO Mol. Med. 6, 496–503 (2014).

Saraswati, S. et al. Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS ONE 5, e15521 (2010).

van Brakel, T. J. et al. Intrapericardial delivery enhances cardiac efects of sotalol and atenolol. J. Cardiovasc. Pharmacol. 44, 50–56 (2004).

William Whyte, Ellen T. Roche, Claudia E. Varela, Keegan Mendez et al. "Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir" , Nature Biomedical Engineering, 2018




DOI: https://doi.org/10.37591/rrjohp.v9i2.1532

Refbacks

  • There are currently no refbacks.


Copyright (c) Research & Reviews: A Journal of Health Professions

This Journal archive has been shifted to: https://journals.stmjournals.com/archive/rrjohp/