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Various Aging Factors and Their Significant Impacts on the Skin

Abhishek Kumar, Anuska Singh, Shubham Tripathi, Vidisha Bajpai


As the average lifespan in developed nations rises, proper aged skin care has become a dermatological concern. The complicated, multifaceted process of skin aging has a genetically established baseline pace but can also be sped up by socioeconomic, mechanical, or environmental variables. Skin fragility, skin resiliency, the danger of toxicological injuries, the promotion of the development of different cutaneous illnesses, and aesthetically unfavorable consequences like wrinkles and uneven pigmentation are all increased by the fundamental structural changes that take place with skin aging. Because older patients make up a higher portion of the population, it will be essential to pay more attention to the issues with more aged skin, both aesthetic and non-cosmetic, and to build on the effective treatments already in place to enhance their quality of life. According to specific reports, age, and overall inner- health state are reflected in the skin. Science and medicine throughout the world have long found nutrition and how it affects the skin to be fascinating topics. To maintain a youthful skin look, several plant extracts, including vitamins, carotenoids, tocopherols, flavonoids, and others, have been widely employed in the skin care business as dietary supplements or topically applied treatments.


Aging skin, free radicals, photo-aging, collagen, dermis

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Makrantonaki E, Zouboulis CC. Characteristics and pathomechanisms of endogenously aged skin. Dermatology. 2007; 214(4): 352–60.

Polefka TG, Meyer TA, Agin PP, Bianchini RJ. Effects of Solar Radiation on the Skin. J Cosmet Dermatol. 2012 Jun; 11(2): 134–43.

Farage MA, Miller KW, Elsner P, Maibach HI. Structural Characteristics of the Aging Skin: A Review. Cutan Ocul Toxicol. 2007 Jan 10; 26(4): 343–57.

Mohiuddin AK. Skin aging & modern age anti-aging strategies. Pharma Tutor. 2019; 7(8): 22–70.

Morganti P, Brunoy C, Guarneri F, Cardillo A, Ciotto P Del, Valenzanoz F. Role of topical and nutritional supplement to modify the oxidative stress. Int J Cosmet Sci. 2002 Dec; 24(6): 331–9.

Hwang K-A, Yi B-R, Choi K-C. Molecular mechanisms and in vivo mouse models of skin aging associated with dermal matrix alterations. Lab Anim Res. 2011; 27(1): 1–8.

Morita A, Torii K, Maeda A, Yamaguchi Y. Molecular basis of tobacco smoke-induced premature skin aging. J Investig Dermatol Symp Proc; Elsevier; 2009 Aug; 14(1): 53–5.

Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermato-Endocrinol. 2012 Jul 1; 4(3): 308–19.

Zouboulis CC, Ganceviciene R, Liakou AI, Theodoridis A, Elewa R, Makrantonaki E. Aesthetic aspects of skin aging, prevention, and local treatment. Clin Dermatol. 2019 Jul 1; 37(4): 365–72.

Šitum M, Buljan M, Čavka V, Bulat V, Kroll I, Lugović Mihić L. Skin changes in the older adults– how big is the influence of the UV radiation on skin aging? Coll Antropol. 2010; 34(2): 9–13.

Addor FAS. Beyond photoaging: additional factors involved in the process of skin aging. Clin Cosmet Investig Dermatol. 2018; 11: 437–443.

Poljšak B, Dahmane R. Free radicals and extrinsic skin aging. Dermatol Res Pract. 2012; 2012: 135206.

Farage MA, Miller KW, Elsner P, Maibach HI. Structural characteristics of the aging skin: A review. Cutan Ocul Toxicol. 2007 Oct; 26(4): 343–57.

Treiber N, Maity P, Singh K, Ferchiu F, Wlaschek M, Scharffetter-Kochanek K. The role of manganese superoxide dismutase in skin aging. Dermatoendocrinol. 2012; 4(3): 232–5.

Burke KE. Mechanisms of aging and development—A new understanding of environmental damage to the skin and prevention with topical antioxidants. Mech Ageing Dev; Elsevier Ireland Ltd. 2018 Jun; 172: 123–30.

Wu Y, Kalra P, Moccozet L, Magnenat-Thalmann N. Simulating wrinkles and skin aging. Vis Comput. 1999; 15(4): 183–98.

Kim M, Park HJ. Molecular mechanisms of skin aging and rejuvenation. Mol Mech Aging Process Rejuvenation. InTech. 2016; 450.

Ansary TM, Hossain MR, Kamiya K, Komine M, Ohtsuki M. Inflammatory molecules associated with ultraviolet radiation-mediated skin aging. Int J Mol Sci. 2021; 22(8): 3974.

Sator P, Schmidt JB, Rabe T, Zouboulis CC. Skin aging and sex hormones in women–clinical perspectives for intervention by hormone replacement therapy. Exp Dermatol. 2004; 13(Suppl 4): 36–40.

Gilchrest BA. Skin aging and photoaging. Dermatol Nurs. 1990; 2(2): 79–82.

Ahmed IA, Mikail MA, Zamakshshari NH, Mustafa MR, Hashim NM, Othman R. Trends and challenges in phytotherapy and Phyto cosmetics for skin aging. Saudi J Biol Sci. 2022; 29(8): 103363.

Schagen SK, Zampeli VA, Makrantonaki E, Zouboulis CC. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012 Jul 1; 4(3): 298–307.

McDaniel D, Farris P, Valacchi G. Atmospheric skin aging—Contributors and inhibitors. J Cosmet Dermatol; Blackwell Publishing Ltd. 2018 Apr; 17(2): 124–37.

Baumann L. Skin aging and its treatment. J Pathol. 2007; 211(2): 241–51.

Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol. 2012; 4(3): 308–19.

Palmer DM, Kitchin JS. Oxidative damage, skin aging, antioxidants, and a novel antioxidant rating system. J Drugs Dermatol (JDD). 2010; 9(1): 11–5.

Menaa F, Menaa A, Tréton J. Polyphenols against skin aging. In: Polyphenols in Human Health and Diseases. Elsevier. 2014; 1: 819–30.


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