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Infant’s Immunity w.s.r. to Compliment System: A General Review

Gyanendra kumar Gupta, Gagan Devi

Abstract


Infant’s mortality and morbidity rate in developing countries are at higher incidence due to infections. Various factors are responsible for infections, such as low socio-economic status, poor hospital facilities and malnutrition etc. The low level of compliment components and serum immunoglobulin in infants has been claimed to be the reason of defective opsonic activity in infants as well as defective generation of chemotaxis activity. Thus immune system during neonatal as well as infancy period has significant role to play in terms of mortality and morbidity status.


Keywords


Infant’s mortality,Infection,Compliment components,Immunoglobulin and Chemotaxis activity.

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References


Guyton and Hall Textbook of Medical Physiology (Guyton Physiology) Hardcover by John E. Hall PhD–Saunders; 13th edition (3 July 2015)

G J Arlaud, et al. The atypical serine proteases of the complement system. Adv Immunol.1998;69:249-307.

Bork P, Downing AK, Kieffer B and Campbell ID (1996) Structure and distribution of modules in extracellular proteins. Quarterly Reviews of Biophysics. 1996:29(2): 119–167.

A W Dodds, et al.The phylogeny and evolution of the first component of complement, C1. Behring Inst Mitt.1993 Dec;(93):87-102.

M M Frank, et al.The role of complement in inflammation and phagocytosis.Immunol Today.1991 Sep;12(9):322-6.

Law SKA and Reid KBM (1995) Complement. Oxford: IRL Press.

Liszewski MK, Farries TC, Lublin DM, Rooney IA and Atkinson JP.Control of the complement system. Adv Immunol.1996;61:201-83.

Morgan BP and Gasque P. Expression of complement in the brain: role in health and disease. Immunol Today.1996 Oct;17(10):461-6.

Volanakis JE and Frank MM (eds).The Human Complement System in Health and Disease. New York: M. Dekker.1998.

László Maródi. Neonatal Innate Immunity to Infectious Agents.Infect Immun. 2006 Apr; 74(4): 1999–2006.

Ga Kardar, et al. Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children. Iran J Public Health. 2012;41(7):59-63.

Lewis DB, Tu W. The physiologic,Immunodeficiency of immaturity. In: Stiehm ER,Ochs HD, Winkelstein JA (eds). Immunologic Disorders in infants and children.Philadelphia:Elsevier Saunders Company, fifth Edition,2004:687-760.

Lewis DB, Wilson CB. Developmental,Immunology and role of host defenses in fetal and Neonatal susceptibility to infection. In: Remington JS, Klein JO (eds). Infectious Diseases of the Fetus and Newborn Infant. Philadelphia: WB Saunders Company, Fifth Edition, 2001:25138.

Fanaroff AA, Korones SB, Wright LL, Verter J,Poland RL, Bauer CR, et al. Incidence, presenting Features, risk factors and significance of late onset Septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J 1998;17:593-598.

Avanzini MA, Pignatti P, Chirico G, Gasparoni A, Jalil F, Hanson LA. Placental transfer favours high Avidity igg antibodies. Acta Paediatr.1998 Feb;87(2):180-5.

Gasparoni A, et al. Igg subclasses Compared in maternal and cord serum and breast ,Milk. Arch Dis Child.1992 Jan;67(1 Spec No):41-3.

Thomas Boenisch.Effect of heat-induced antigen retrieval following inconsistent formalin fixation.Appl Immunohistochem Mol Morphol.2005 Sep;13(3):283-6.

Klein, J. & Remington, J. in Infectious Diseases ofthe Fetus and Newborn Infant (eds Remington, J. &Klein, J.) 1–23 (W. B. Saunders Company, Philadelphia,2001)

Goldman AS, Garza C, Schanler RJ, Goldblum RM. Molecular forms of lactoferrin in stool and urine from infants fed human milk. Pediatr Res 1990:27:252–255.

Stephens S, Kennedy CR, Lakhani PK. In-vivo immune,responses of breast- and bottle-fed infants to tetanus toxoid antigen and to normal gut flora. Acta Pædiatrica, 73(4), 426-432.

Hanson LÅ. Comparative immunological studies of the immune globulins of human milk and of blood serum. Int Arch Allergy Appl Immunol 1961;18(5):241–267.

Chiba Y, Minagawa T, Mito K, et al. Effect of breast feeding on responses of systemic interferon and virusspecific lymphocyte transformation in infants with respiratory syncytial virus infection. J Med Virol.1987 Jan;21(1):7-14.

Goldman AS, Thorpe LW, Goldblum RM, Hanson LA. Anti-inflammatory properties of human milk. Acta Paediatr Scand.1986 Sep;75(5):689-95.

Goldblum RM, Schanler RJ, Garza C, Goldman AS. Human milk feeding enhances the urinary excretion of immunologic factors in low birth weight infants. Pediatr Res.1989 Feb;25(2):184-8.

Remington JS, Klein JO. Developmental immunology and role of host defences in fetal and neonatal susceptibility to infection. Infectious diseases of the fetus and newborn infant, 6th ed. Philadelphia: W.B. Saunders. 2006.

Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature.2007 Jul 26;448(7152):484-487.

Development of the Infant Immune Function and the Effects of Breast Milk By Catherine Clinton, ND Natural Medicine Journal. 2010:2(8).




DOI: https://doi.org/10.37591/rrjoi.v11i2.2637

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