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COVID-19: An Emerging Global Threat
Abstract
The emergence of COVID-19 in Wuhan, Hubei Province, China in December 2019 has worsened global health worries. It is now declared by World Health Organization (WHO) as a Public Health Emergency of International Concern (PHEIC). Till 22 March 2021, there have been 122,524,424 confirmed cases of COVID-19 globally, with 2,703,620 deaths, and more than 216 countries are suffering from this fatal virus. The transmission of coronavirus occurs via droplets, filthy hands, and surfaces with an incubation period of 2 to14 days. The speed of the transmission of this lethal infection airs a severe danger to public health. To alleviate COVID-19 patients, it is imperative, to begin with, the initial diagnosis, isolation, and supportive management. As a part of the massive worldwide response to limit and contain the pandemic, an important consideration was placed on producing research intelligence to monitor evidence-based responses to confine the SARS-CoV-2 virus. Currently, the novel variants of the COVID-19 have been detected in the UK, South Africa, and Brazil. These variants represented several mutations on spike proteins. A potential escalation in the transmission of SARS-CoV-2 infection in humans due variants development has raised a serious concern. The present review highlights the general characteristics of SARS-CoV-2, pathogenesis, transmission, diagnosis, epidemiology, and treatment of COVID-19 infection. It also focuses on the current information on new variants of coronavirus-19, emergency use authorization of COVID-19 vaccine, and regulatory requirement for developing and introducingCOVID-19 vaccines in the Indian market.
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References
Lai CC, Liu YH, Wang CY, Wang YH, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths. J Microbiol Immunol Infect. 2020 Jun;53(3):404–412. https://doi.org/10.1016/j.jmii.2020.02.012.
Lupia T, Scabini S, Mornese S, et al. 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge. J Glob Antimicrob Re. 2020; 21: 22–7p.
Shereen MA, Khan S, Kazmi A, Bashir,N, Siddique R. COVID-19 infection: origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020: 24; 91–8p.
Han Q, Lin Q, Jin, S You, et al. Coronavirus 2019-nCoV: A brief perspective from the front line. J Infect. 2020; 80(4): 373–377.
Devaux CA, Rolain JM, Colson P, et al. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? Int J Antimicrob. Agent, https://doi.org/10.1016/j.ijantimicag.2020.105938.
Ghinai I, McPherson TD, Hunter JC, et al. First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA. Lancet. 2020; 395: (10230), 1137–44p.
Li X, Geng M, Peng Y, et al. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020, 10(2),102–108.
Sun J, He WT, Wang L, et al. COVID-19: Epidemiology, evolution, and cross-disciplinary perspectives. Trends Mol Med. 2020; 26(5): 483–95p.
Wu D, Wu T, Liu Q, et al. The SARS-CoV-2 outbreak: What we know. Int J Infect Dis. 2020; 12 (94): 44–8p.
Tang B, Bragazzi NL, Li Q, et al. An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov). Infect Dis Model. 2020: 5; 248–55p.
Su S, Wong G, Sh, W, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016; 24(6): 490-502.
Li H, Liu SM, Yu XH, et al. Coronavirus disease 2019 (COVID-19): current status and future perspective. Int J Antimicrob Agents. 2020 May;55(5):105951. https://doi.org/10.1016/j.ijantimicag.2020.105951.
Wang LS, Wang YR, Ye DW, et al. A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. Int J Antimicrob Agent. 2020 Jun;55(6):105948. https://doi.org/10.1016/j.ijantimicag.2020.105948.
Chen J. Pathogenicity and transmissibility of 2019-nCoV—A quick overview and comparison with other emerging viruses. Microb Infect. 2020: 22(2); 69–71.
Rothan HA, Byrareddy SNJ. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020; 109: 102433.
WHO. Coronavirus disease (COVID-19) pandemic https://www.who.int/emergencies/diseases/novel-coronavirus-2019 (accessed on 11/06/20).
WHO. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/?gclid (accessed on 22/03/21).
WHO. https://who.sprinklr.com/region/searo/country/in (accessed on 11/06/20).
WHO. https://covid19.who.int/region/searo/country/in(accessed on 22/03/21).
Hui DSC, Zumla A. Severe acute respiratory syndrome: Historical, epidemiologic, and clinical features. Infect Dis Clin North Am. 2019; 33(4): 869-89p.
Yang Y, Peng F, Wang R., et al. The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China. J Autoimmun. 2020; 09: 102434.
Zhang R, Wang X, Ni L, et al. COVID-19: Melatonin as a potential adjuvant treatment. Life Sci. 2020; 250: 117583.
Petrosillo N, Viceconte G, Ergonul O, et al. COVID-19, SARS and MERS: are they closely related? Clin Microbiol Infect. 2020 Jun;26(6):729-734. https://doi.org/10.1016/j.cmi.2020.03.026.
Ye G, Pan Z, Pan, Y. et al. Clinical characteristics of severe acute respiratory syndrome coronavirus-2 reactivation. J Infect. 2020; 80(5): e14–e17.
Tian S, Hu N, Lou, J. et al. Characteristics of COVID-19 infection in Beijing. J Infect. 2020; 80(4): 401–6p.
Huang C, Wang Y, Li, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 2020; 395 (10223):497–506p.
Rodriguez-Morales AJ, Cardona-Ospina JA. Villamizar-Peña R, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020; 34: 101623.
Kooraki S, Hosseiny M, Myers L, et al. Coronavirus (COVID-19) outbreak: What the department of radiology should know. J Am Coll Radiol. 2020; 17(4):447–51p.
Huang Z, Zhao S, Li Z, et al. The battle against coronavirus disease 2019 (COVID-19): Emergency management and infection control in a radiology department. J Am Coll Radiol. 2020; Mar 24; S1546-1440(20)30285-4.doi:10.1016/j.jacr.2020.03.011.
Zhai P, Ding Y, Wu X, et al. The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents, 2020 May;55(5):105955. https://doi.org/10.1016/j.ijantimicag.2020.105955.
Choon-Huat Koh, G Hoenig H. How should the rehabilitation community prepare for 2019-nCoV? Arch Phys Med Rehabil. 2020 Jun;101(6):1068-1071. https://doi.org/10.1016/j.apmr.2020.03.003.
Jean SS, Lee PI, Hsueh PR. Treatment options for COVID-19: The reality and challenges. 2020 Jun;53(3):436–443. J Microbiol Immunol Infect. https://doi.org/10.1016/j.jmii.2020.03.034.
Sallard E, Lescure FX, Yazdanpanah Y, et al. Type 1 interferons as a potential treatment against COVID-19. Antivir Res.2020,178, 104791.
Sahraei Z, Shabani M, Shokouhi S, et al. Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine. Int J Antimicrob Agents. 2020; 55(4):105945.
AminJafari A, Ghasemi S.The possible of immunotherapy for COVID-19: A systematic review. Int. Immunopharmacol. 2020: 83:106455.
NIH. What's New in the Guidelines. https://www.covid19treatmentguidelines.nih.gov/whats-new/ (accessed on 23/05/20)
NIH. NIH clinical trial testing antiviral remdesivir plus anti-inflammatory drug baricitinib for COVID-19 begins. https://www.nih.gov/news-events/news-releases/nih-clinical-trial-testing-antiviral-remdesivir-plus-anti-inflammatory-drug-baricitinib-covid-19-begins (accessed on 23/05/20).
NIH. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. https://www.covid19treatmentguidelines.nih.gov/ accessed on
NIH. Isotretinoin in Treatment of COVID-19 (Randomized). https://clinicaltrials.gov/ct2/show/NCT04361422?cond=COVID 19&draw=2&rank=9 (accessed on 23/05/20).
WHO. COVID-19 vaccines. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/covid-19-vaccines (accessed on 22/12/20)
FDA. Comirnaty and Pfizer-BioNTech COVID-19 Vaccine. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/pfizer-biontech-covid-19-vaccine (accessed on 22/12/20).
FDA. Moderna COVID-19 Vaccine. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/moderna-covid-19-vaccine#additional (accessed on 22/12/20).
Letter from Additional Secretary, MoHFW regarding Contraindications and Factshe. https://www.mygov.in/covid-advisories/letter-additional-secretary-mohfw-regarding-contraindications-and-factsheet-covid/ (accessed on 21/01/20021)
Ministry of Health & Family Welfare Government of India. Covid 19 Vaccines Operational Guidelines. https://www.mohfw.gov.in/pdf/COVID19VaccineOG111Chapter16.pdf (accessed on 22/01/21).
Regulatory guidelines for development of vaccines with special consideration for COVID-19 vaccine, https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadPublic_NoticesFiles/Regulatory_guidelines_for__development_of_Vaccine_20.9.20.pdf (accessed on 21.09.2020).
New Drugs and Clinical Trials Rules, 2019 published on 19/03/2019, https://cdsco.gov.in/opencms/export/sites/CDSCO_WEB/Pdf-documents/NewDrugs_CTRules_2019.pdf
Centers for Disease Control. What You Need to Know About Variants. https://www.cdc.gov/coronavirus/2019-ncov/transmission/variant.html(accessed on 30/01/21).
Centers for Disease Control. Variant Proportions. https://www.cdc.gov/coronavirus/2019-ncov/transmission/variant-cases.html (accessed on 30/01/21).
Centers for Disease Control. Variants and Genomic Surveillance for SARS-CoV-2. https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html (accessed on 30/01/21).
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