Open Access Open Access  Restricted Access Subscription or Fee Access

Effect of Unani Pharmacopeial Formulation Damavi on Iron Profile in Cases of Anaemia

Priyanka Verma

Abstract


Anaemia is decrease in red blood cells or haemoglobin in blood; its frequency is around 2.36 billion i.e. 33% in 2015. Important symptoms associated include paleness of skin, weakness, shortness of breath, poor ability to exercise, etc. Many Unani formulations are used for treating anaemia but in this study, Tab. Damavi was used to see its effect on iron profile. This study was carried out at Regional Research Institute of Unani medicine, New Delhi. For this, 32 female patients in the age group of 18–65 years attending OPD were selected with 8–11 g/dl of haemoglobin with or without the following signs and symptoms which include pallor, weakness, fatigue, and dyspnoea. After completion of study, data obtained was analyzed statistically, significance level of p <0.05 was used. Post treatment there was improvement in iron profile and complete blood count which includes increase (p<0.05) in iron (26.84%), ferritin (71.56%), transferrin saturation (34.20%), haemoglobin (16.83%), hematocrit (10.3%), mean corpuscular volume (7.47%), mean corpuscular haemoglobin (13.13%) and mean corpuscular haemoglobin concentration (3.93%) while total iron binding capacity decreases (p>0.05) by 7.19%. No adverse event is reported as kidney and liver function tests were normal. This shows that Tab. Damavi is not only safe, it also help in improving iron profile, by increasing haemoglobin or relieving anaemia. 


Keywords


Anaemia, Damavi, iron profile, CBC, Unani formulation

Full Text:

PDF

References


NCBI. Anemia. (Jan, 2022). Available Online at: https://www.ncbi.nlm.nih.

gov/books/NBK499994/#:~:text=Anemia%20is%20a%20reduction%20in,lethargy%2C%20weakness%2C%20and%20tiredness.

Thomas Lathrop Stedman. Stedman’s Medical Dictionary. 28th edition. Philadelphia: Lippincott Williams & Wilkins; Feb 2006.

Bernadette F Rodak, et al. Hematology: Clinical Principles and Applications. Saunders; 3rd edition. Mar 2007.

National Health Portal. Soo-ul-Qinya (Anaemia). (May, 2015). Available Online at: https://www.nhp.gov.in/soo-ul-qinya-anaemia_mtl.

Stein J, Connor S, Virgin G, Ong DE, Pereyra L. Anemia and iron deficiency in gastrointestinal and liver conditions. World Journal of Gastroenterology. 2016; 22(35): 7908–7925.

Koury MJ, Ponka P. New insights into erythropoiesis: The roles of folate, vitamin B12, and iron. Annu. Rev. Nutr. 2004; 14(24): 105–131.

Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: A systematic analysis for the global burden of disease study 2010. The Lancet. 2012; 380(9859): 2163–2196.

Abubakar II, Tillmann T, Banerjee A. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the global burden of disease study 2013. Lancet. 2015; 385(9963): 117–171.

Johnson RL, Rubenstein SD. Anemia in the emergency department: Evaluation and treatment. Emergency Medicine Practice. 2013; 15(11): 1–5.

DeMaeyer EM, Dallman P, Gurney JM, Hallberg L, Sood SK, Srikantia SG. Preventing and controlling iron deficiency anaemia through primary health care: A guide for health administrators and programme managers by World Health Organization (WHO). (July 1989).

Quintó L, Aponte JJ, Menéndez C, Sacarlal J, Aide P, Espasa M, Mandomando I, Guinovart C, Macete E, Hirt R, Urassa H. Relationship between haemoglobin and haematocrit in the definition of anaemia. Tropical Medicine & International Health. 2006; 11(8): 1295–1302.

H Kenneth Walker et al.‎ Clinical Methods: The History, Physical and Laboratory Examinations. 3rd edition. Butterworth-Heinemann Ltd; April 1990.

Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, Present and future. Biochem Biophys Acta. 2010; 1800(8): 760–769.

Hetet G, Devaux I, Soufir N, Grandchamp B, Beaumont C. Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations. Blood. 2003; 102(5): 1904–1910.

Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y. Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity. Clinical Chemistry. 2003; 49(1): 175–178.

Kasvosve I, Delanghe J. Total iron binding capacity and transferring concentration in the assessment of iron status. Clin Chem Lab Med. 2002; 40(10): 1014–1018.

Gambino R, Desvarieux E, Orth M, Matan H, Ackattupathil T, Lijoi E, Wimmer C, Bower J, Gunter E. The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum. Clinical Chemistry. 1997; 43(12): 2408–2412.

Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food and Nutrition Bulletin. 2008; 29(2_suppl 1): S126–S131.

Zeuschner CL, Hokin BD, Marsh KA, Saunders AV, Reid MA, Ramsay MR. Vitamin B12 and vegetarian diets. Medical Journal of Australia. 2013; 199: S27–S32.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Research & Reviews: A Journal of Immunology