A Case Report on Alport Syndrome which ends up with Allograft Rejection due to Anti-GBM Disease

Abstract

Alport syndrome (AS) is a condition which is genetically inherited and is characterized by abnormalities in the basement membrane of the kidney, ear and eye as well. It is one of the spectra of diseases representing hereditary nephritis, which inevitably leads to end-stage renal disease (ESRD). Sensorineural hearing loss (SNHL) is also a characteristic feature in AS. The hearing abnormality begins during late childhood or early adolescence and 90% of the individuals become deaf by the age of 40 years. The chief ocular findings include anterior lenticonus, cataract, central and midperipheral retinal flecks. Other ocular changes include corneal arcus, recurrent corneal erosion, posterior lenticonus, posterior polymorphus dystro­phy and macular degeneration; finally, they end up with vision loss. Here I report a case of AS with all the characteristic features.

Keywords: Alport syndrome (AS), hematuric nephritis, sensorineural deafness, anterior lenticonus, proteinuria

Cite this Article

Ansu Ann Mathew A Case Report on Alport Syndrome which ends up with Allograft Rejection due to Anti-GBM Disease. Research & Reviews: Journal of Medicine. 2019; 9(3): 1–4p.