Experimental Study on the Effect of Combination of Two Ginseng-Containing Prescriptions of Koryo Herbal Medicines and Fluconazole in Systemic Candidiasis Mouse Model

Authors

  • Gum-Ryon Jang Pyongyang Medical Collage, KIM IL SUNG University
  • Ryo-Hyon Won Pyongyang Medical Collage, KIM IL SUNG University
  • Ye-Rim Ri Pyongyang Medical Collage, KIM IL SUNG University

DOI:

https://doi.org/10.37591/rrjom.v10i1.1883

Abstract

We evaluated the efficacy of two Ginseng-containing prescriptions of Koryo herbal medicines combined with fluconazole (FLC) against systemic candidiasis, using experimental mouse model. The results showed that combined with FLC, treatment of mice with Sa-Gun-Za-Tang or Sip-Zon-Dae-Bo-Tang significantly increased the survival rates and decreased the number of viable Candida albicans cells in the kidneys compared with treating animals with FLC alone(P<0.01 for both comparisons). Compared with untreated controls, treatment of mice with FLC alone did not increase the number of leukocytes significantly (P>0.05), but with FLC+Sa-Gun-Za-Tang or FLC+Sip-Zon-Dae-Bo-Tang combination significantly increased (P<0.01 for both comparisons) the number of leukocytes. FLC+Sa-Mul-Tang has no potent activity against systemic candidiasis both in terms of improved survival and the number of leukocytes and reduction in organ burden in a murine model (P>0.05).

 

Keywords: Fluconazole (FLC), herbal medicine, systemic candidiasis, Sip-Zon-Dae-Bo-Tang, Sa-Gun-Za-Tang

 

Cite this Article

Gum-Ryon Jang, Ryo-Hyon Won, Ye-Rim Ri. Experimental Study on the Effect of Combination of Two Ginseng-Containing Prescriptions of Koryo Herbal Medicines and Fluconazole in Systemic Candidiasis Mouse Model. Research & Reviews: A Journal of Medicine. 2020; 10(1): 24–28p.

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Published

2020-05-15

Issue

Vol. 10 No. 1 (2020)

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Articles

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