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Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli

Kanhaiya M Dadure, Animeshchandra G M Haldar, Debarshi Kar Mahapatra

Abstract


Abstract

Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and ultimately screened for its anti-bacterial potentials against gram-negative microbial species (Escherichia coli) and gram-positive microbial species (Staphylococcus aureus) using the conventional procedure. The chemical structure of the proposed molecule was completely recognized by sophisticated spectroscopic instruments. The compound exhibited an incredible anti-bacterial activity against anti-E. coli and expressed a fair bacterial activity against anti-S. aureus in in-vitro anti-microbial screening model, but with a very low potency. The compound was found to be more effective towards gram-negative species. The investigation pointed towards several prospective for the development of broad-spectrum anti-microbial drugs against resistant pathogenic strains by looking insights into the unexplored class of thiophene-containing chalcone compound.

Keywords: Anti-microbial, chalcone, Escherichia coli, Staphylococcus aureus, Thiophene synthesis

Cite this Article

Kanhaiya M. Dadure, Animeshchandra G.M. Haldar, Debarshi Kar Mahapatra. Development and Applications of a Simple Chalcone-Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli. Research & Reviews: Journal of Medicine. 2020; 10(2): 14–18p.



Keywords


Chalcone, Thiophene, Synthesis, Escherichia coli, Staphylococcus aureus, Anti-microbial

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References


Mahapatra DK, Bharti SK, Asati V. Chalcone derivatives: Anti-inflammatory potential and molecular targets perspectives. Curr Top Med Chem. 2017;17(28):3146-3169p.

Mahapatra DK, Bharti SK, Asati V. Anti-cancer Chalcones: Structural and molecular targets perspectives. Eur J Med Chem. 2015;98:69-114p.

Mahapatra DK, Bharti SK, Asati V. Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives. Eur J Med Chem. 2015;101:496-524p.

Mahapatra DK, Asati V, Bharti SK. Chalcones and their role in management of diabetes mellitus: Structural and pharmacological perspectives. Eur J Med Chem. 2015;92:839-865p.

Mahapatra DK, Bharti SK. Therapeutic Potential of chalcones as cardiovascular agents. Life Sci. 2016;148:154-172p.

Mahapatra DK, Bharti SK, Asati V, Singh SK. Perspectives of medicinally privileged chalcone based metal coordination compounds for biomedical applications. Eur J Med Chem. 2019;174:142-158p.

Mahapatra DK, Asati V, Bharti SK. An updated patent review of therapeutic applications of chalcone derivatives (2014-present). Exp Opin Therapeut Pat. 2019;29(5):385-406p.

Mahapatra DK, Asati V, Bharti SK. Recent therapeutic progress of chalcone scaffold bearing compounds as prospective anti-gout candidates. J Crit Rev. 2019;6(1):1-5p.

Mahapatra DK, Shivhare RS, Kumar P. Murrayanine-chalcone transformed into novel pyrimidine compounds demonstrated promising anti-inflammatory activity. Asian J Pharm Res. 2018;8(1):6-10p.

Mahapatra DK, Shivhare RS, Bharti SK. Novel Murrayanine based Pyrazole analogs as emerging anti-fungal candidates: Design, synthesis, characterization, and in vitro evaluation. Res Pharm. 2017;1(1):1-5p.

Mahapatra DK, Chhajed SS, Shivhare RS. Development of Murrayanine-Chalcone hybrids: An effort to combine two privilege scaffolds for enhancing hypoglycemic activity. Int J Pharm Chem Anal. 2017;4(2):30-34p.

Mahapatra DK, Shivhare RS. 3′,4′-Methylenedioxy Moiety Containing Murrayanine Based Chalcone as Emerging Anti-inflammatory Agent. J Mod Chem Chem Technol. 2018;9(1):12-16p.

Mahapatra DK, Shivhare RS, Asati V. Locomotor inhibitory activity of some Murrayanine-Chalcone based 2,3-dihydrobenzo[b][1,4]thiazepine derivatives: Exploring Anxiolytic potentials. Chron Pharm Sci. 2018;2(1):462-468p.

Mahapatra DK, Shivhare RS, Dadure KM. Transforming Murrayanine-Chalcone into corresponding 3H-benzo[b][1,4]diazepine derivatives: Accessing the anti-anxiety effect by inhibition of locomotor activity. Acta Scientific Pharm Sci. 2018;2(5):40-44p.

Mahapatra DK, Shivhare RS, Joseph TM. Design and characterization of Murrayanine linked Isoxazole derivatives: Novel class of bacteriocidal agents. Int J Res Drug Pharm Sci. 2017;1(1):11-15p.

Mahapatra DK, Shivhare RS. Anti-microbial Perspective of a Chalcone, (E)-1-(1-methoxy-9H-carbazol-3-yl)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-one: Fabrication of a Hybrid by Unification of a Natural Product with a Synthetic Component. Int J Agri Life Sci. 2018;4(2):236-240p.




DOI: https://doi.org/10.37591/rrjom.v10i2.2059

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