Formulation and Evaluation of a Herbal Mosquito Repellent

Authors

  • Blessy Jacob Assistant Professor, Department of Pharmacy, T John College of Pharmacy, BG Road, Gottigere, Bangalore, Karnataka, India
  • Lokesh Yadav Student, Department of Pharmacy, T John college of Pharmacy, BG Road, Gottigere, Bangalore, Karnataka, India
  • Vineeth Chandy Principal, Department of Pharmacy, T John College of Pharmacy, BG Road, Gottigere, Bangalore, Karnataka, India

Keywords:

Mosquito repellent, DEET, sesquiterpenoids, scopoletin, flavonoids, quercetin, kaempferol

Abstract

Mosquito bites can give an unpleasant feeling and are attracted to human blood containing protein to develop their eggs, biting human to another human, thereby transmitting the vector disease to human. Many species of mosquitoes are vectors of several disease causing pathogens such as dengue, zika and yellow fever. Dengue fever and yellow fever can cause severe human morbidity and mortality. Over one million people worldwide die from mosquito diseases every year because of the diseases causes by mosquitoes. The ideal method for controlling mosquitoes using larvicides and targeting the breeding places. In this present scenario synthetic compound DEET are effectively used as mosquito repellents whereas to its contradictory numbers of adverse effects were observed. DEET is a N, N-diethyl-m-toluamide, also called N, N-diethyl-3-methylbenzamide. It has an unpleasant odour and strong penetration into the skin which can be harmful to the human. The uses of plant extract can reduce the uses of chemical in mosquito repellent. Marigold flowers contains many chemicals constituents such as cadinol, carotenoids, isorhamnetin, saponins, triterpenes, sesquiterpenoids, scopoletin, flavonoids, quercetin, kaempferol, which has proved to have various biological properties along with mosquito repellent properties. In this research comparison studies of marigold flowers extract and synthetic chemical used as mosquito repellents was carried out.

References

Pichersky E, Gershenzon J: The formation and function of plant volatiles: perfumes for pollinator attraction and defense. Curr Opinion Plant Biology. 2002, 5(3): 237-243. 10.1016/S1369-5266(02)00251-0.

Harrewijn P, Minks AK, Mollema C: Evolution of plant volatile production in insect-plant relationships. Chemoecology. 1995, 5: 55-73. 10.1007/BF01259434.

Ditzen M, Pellegrino M, Vosshall LB: Insect odorant receptors are molecular targets of the insect repellent deet. Science. 2008, 319(5871): 1838-1842. 10.1126/science.1153121

Pitts RJ, Fox AN, Zwiebel LJ: A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector, Anopheles gambiae. Proc Natl Acad Sci U S A. 2004, 101(14): 5058-5063.

Hallem EA, Dahanukar A, Carlson JR: Insect odor and taste receptors. Annu Rev Entomol. 2006, 51: 113-135.

Gatehouse JA: Plant resistance towards insect herbivores: a dynamic interaction. New Phytologist. 2002, 156. Available online at: https://nph.onlinelibrary.wiley.com/doi/full/10.1046/j.1469-8137.2002.00519.x#:~:text=Plants%20also%20respond%20to%20insect,plants%2C%20to%20induce%20defence%20responses.&text=Herbivorous%20insects%20have%20adapted%20to,also%20be%20constitutive%20or%20induced.

Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR: Odorant reception in the malaria mosquito Anopheles gambiae. Nature. 2010, 464: 66-71. 10.1038/nature08834.

Logan JG, Stanczyk NM, Hassanali A, Kemei J, Santana AEG, Ribeiro KAL, Pickett JA, Mordue (Luntz) JA: Arm-in-cage testing of natural human-derived mosquito repellents. Malar J. 2010, 9: 239-10.1186/1475-2875-9-239.

Syed Z, Leal WS: Mosquitoes smell and avoid the insect repellent DEET. Proc Natl Acad Sci U S A. 2008, 10: 1073-

Kwon Y, Kim SH, Ronderos DS, Lee Y, Akitake B, Woodward OM, Guggino WB, Smith DP, Montell C: Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 2010, 20: 1672-1678. 10.1016/j.cub.2010.08.016.

World Health Organization. World Malaria Report 2018; WHO: Geneva, Switzerland, 2018.

Pukrittayakamee S et al. Malaria. Lancet 2014; 383;: 723–735

Jasminka et al. “Malaria: The Past and the Present.” Microorganisms June 2019; 7,6;:179.21

Shubhangi Sharad Bhide et al. Development of mosquito repellent formulations and evaluation for its activity. World Journal of Pharmaceutical Research. 2014; 3(2): 2910-2917

Braverman Y et al. Mosquito repellent attracts Culicoides imicola (Diptera: Ceratopogonidae). Journal of Medical Entomology,1999; 36(1): 113–115.

Mohini M et al. Evaluation of anti mosquito properties of essential oils. Journal of Scientific and Industrial Research, 2005; 64: 129-133.

Ansari MA et al. Larvicidal and Mosquito repellent activity of peppermint (Mentha piperita) Oil. Bioresource Tecnology, 2000; 71(3): 267-271.

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Published

2022-02-19

Issue

Vol. 12 No. 1 (2022)

Section

Research Article

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