An Experimental Pathological Study on the Prophylactic Effect of N-acetylcysteine on Alopecia from Anti-cancer Drugs

Authors

  • Kwang-U Jon Pyongyang University of Medical Sciences
  • Chol-Su Kim Pyongyang University of Medical Sciences
  • Chol-Jun Ho Pyongyang University of Medical Sciences

Keywords:

Alopecia, N-acetylcysteine, cyclophosphamide, anti-cancer drugs, chemotherapy

Abstract

Prevention of alopecia from anti-cancer drug, Cyclophosphamide, is important for improving quality of life in patients with cancer. Empirically, when Cyclophosphamide (150 mg/kg) infused to rats subcutaneously and intraperitoneally, severe alopecia developed in rats infused intraperitoneally. Moreover, rats infused both of N-acetylcysteine and Cyclophosphamide showed less skin vasculature and scaring of hair follicle, larger caliber of hair follicle and hair, thicker medullary and cortical layers and epimysium, and denser hair follicle, as compared to rats infused Cyclophosphamide alone on day 15. Thus, N-acetylcysteine has preventive effect on alopecia from Cyclophosphamide, which can be useful for the treatment of cancer patients in clinical practice.

References

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Francesco DA, Fialo P, Pennisi TM, Flora SD. Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6. Journal of Dermatological Science. 2007; 46: 189–198p.

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Published

2023-05-05

Issue

Vol. 13 No. 1 (2023)

Section

Research Article

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