A Forensic Study on Serum Leucine Aminopeptidase Activity Alteration in Carbon Monoxide Poisoning

Authors

  • Ri Kun Son Researcher, Department of Forensic Medicine1, Pyongyang University of Medical Science, Pyongyang, Democratic People’s Republic of Korea
  • O In- Taek
  • Kang Jong Hyok
  • O Hyang Mi

DOI:

https://doi.org/10.37591/rrjomst.v12i2.3277

Keywords:

Carbon Monoxide poisoning, LAP (Leucine aminopeptidase), Forensic examination, Monoxide poisoning in mice, Biochemical assay.

Abstract

Background: Recently, Carbon Monoxide poisoning is diagnosed medicolegally depended on poison analytic chemistry and not in biochemical method. Methods: This essay was confirmed the activation change of LAP in Carbon Monoxide poisoning. The LAP activation level was higher than normal in a death with CO poisoning. Because of the Carbon Monoxide poisoning, patients were admitted to the hospital and were cured during a certain period of time. After that, the cause of death was found based on the serum LAP activation level in the cases of sudden death. Result: Serum LAP activation level was from 60U/L to 190 U/L and 96.52±1.24 U/L in average. After poisoning, the LAP level was 150.5±1.24/L in 7-15 days, and 90.32±1.04U/L in 21-30 days. Conclusion: If the patient was suddenly dead after treatment, the CO poisoning could be diagnosed by Leucine aminopeptidase activation level.

References

Townsend, C. L., & Maynard, R. L. (2002). Effects on health of prolonged exposure to low concentrations of carbon monoxide. Occupational and Environmental Medicine, 59(10), 708-711.

Rose, Jason J., Ling Wang, Qinzi Xu, Charles F. McTiernan, Sruti Shiva, Jesus Tejero, and Mark T. Gladwin. "Carbon monoxide poisoning: pathogenesis, management, and future directions of therapy." American journal of respiratory and critical care medicine 195, no. 5 (2017): 596-606.

Chiew, Angela L., and Nicholas A. Buckley. "Carbon monoxide poisoning in the 21st century." Critical Care 18 (2014): 1-8.

D Pankow, W Ponsold, and Hans Fritz, “Combined Effects of Carbon Monoxide and Ethanol on the Activities of Leucine Aminopeptidase and Glutamic-Pyruvic Transaminase in the Plasma of Rats,” Archives of Toxicology 32, no. 4 (January 1, 1974): 331–40, .

Weaver, Lindell K. "Carbon monoxide poisoning." New England Journal of Medicine 360, no. 12 (2009): 1217-1225.

Raub, J.A., Mathieu-Nolf, M., Hampson, N.B. and Thom, S.R., 2000. Carbon monoxide poisoning—a public health perspective. Toxicology, 145(1), pp.1-14..

Chen, Su-Hua, Min-Jie Cao, Wen-Jin Su, and Guo-Ping Wu. "Purification and characterization of a novel leucine aminopeptidase from the earthworm Eisenia foetida." Process biochemistry 46, no. 8 (2011): 1641-1648.

Cho, C. H., Chiu, N. C., Ho, C. S., & Peng, C. C. (2008). Carbon monoxide poisoning in children. Pediatrics & Neonatology, 49(4), 121-125.

Macnow, T.E. and Waltzman, M.L., 2016. Carbon Monoxide Poisoning In Children: Diagnosis And Management In The Emergency Department. Pediatric emergency medicine practice, 13(9), pp.1-24. 10.Teksam, O., Gumus, P., Bayrakci, B., Erdogan, I. and Kale, G., 2010. Acute cardiac effects of carbon monoxide poisoning in children. European Journal of Emergency Medicine, 17(4), pp.192-196.

Martin, James D., Kevin C. Osterhoudt, and Stephen P. Thom. "Recognition and management of carbon monoxide poisoning in children." Clinical Pediatric Emergency Medicine 1, no. 3 (2000): 244-250.

Blumenthal I. Carbon monoxide poisoning. Journal of the royal society of medicine. 2001 Jun;94(6):270-2.

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Published

2023-09-29

Issue

Vol. 12 No. 2 (2023)

Section

Research Article

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