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A Forensic Study on Serum Leucine Aminopeptidase Activity Alteration in Carbon Monoxide Poisoning

Ri Kun Son, O In- Taek, Kang Jong Hyok, O Hyang Mi

Abstract


Background: Recently, Carbon Monoxide poisoning is diagnosed medicolegally depended on poison analytic chemistry and not in biochemical method. Methods: This essay was confirmed the activation change of LAP in Carbon Monoxide poisoning. The LAP activation level was higher than normal in a death with CO poisoning. Because of the Carbon Monoxide poisoning, patients were admitted to the hospital and were cured during a certain period of time. After that, the cause of death was found based on the serum LAP activation level in the cases of sudden death. Result: Serum LAP activation level was from 60U/L to 190 U/L and 96.52±1.24 U/L in average. After poisoning, the LAP level was 150.5±1.24/L in 7-15 days, and 90.32±1.04U/L in 21-30 days. Conclusion: If the patient was suddenly dead after treatment, the CO poisoning could be diagnosed by Leucine aminopeptidase activation level.

Keywords


Carbon Monoxide poisoning, LAP (Leucine aminopeptidase), Forensic examination, Monoxide poisoning in mice, Biochemical assay.

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References


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DOI: https://doi.org/10.37591/rrjomst.v12i2.3277

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