Open Access Open Access  Restricted Access Subscription or Fee Access

Case Control Analysis on Neurodegeneration Disorders and Autism in Familial Context

Ayushi Rai, Neelam Balekar

Abstract


Neurodegenerative disorders such as Parkinson's and Alzheimer's co-occur with autism spectrum disorder (ASD), indicating shared genetic factors. Oxidative stress and inflammation play roles, with an elevated risk of Parkinson's and dementia in individuals with autism spectrum disorder. Antioxidant levels are linked to language and behaviour in autistic children. In the present study, a systematic review and meta-analysis was done following the PRISMA guidelines, reviewing English articles (2002- 2022) on familial coaggregation between autism spectrum disorderand neurodevelopmental disorders in 14 randomized-controlled trials, using PICOS framework. The results of meta-analysis found a significant association (OR 0.21 [0.16, 0.26]) between family history of neurodegenerative disorders and comorbid autism spectrum disorder. Moderate heterogeneity (I2=37%) and no publication bias in funnel plots was observed. Neurodegeneration shares etiological factors and familial correlations with autism spectrum disorder, suggesting shared genetics. High heritability of autism, but transmission across generations not confirmed, necessitating further research. The present study indicated a significant familial link between neurodegenerative disorders and autism spectrum disorder comorbidities, suggesting shared mechanisms. Interdisciplinary collaboration and further research are essential for therapeutic insights.

Keywords


Neurodegenerative disorders, autism spectrum disorder, familial association, shared genetic factors, therapeutic interventions.

Full Text:

PDF

References


Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R. Analysis of shared heritability in common disorders of the brain. Science. 2018; 360(6395): 87p. doi: 10.1126/science.aap8757

Gogtay NJ, Thatte UM. An Introduction to Meta-Analysis. J Assoc Physicians India. 2017; 65(12): 78–85p. PMID: 31556276.

Ashmawi NS, Hammoda MA. Early Prediction and Evaluation of Risk of Autism Spectrum Disorders. Cureus. 2022; 14(3): e23465. doi: 10.7759/cureus.23465. PMID: 35481307; PMCID: PMC9034898.

Brimacombe M, Xue Ming, Parikh A. Familial risk factors in autism. J Child Neurol. 2007; 22(5): 593–597p. doi: 10.1177/0883073807302609. PMID: 17690067.

Ghirardi L, Brikell I, Kuja-Halkola R, Freitag CM, Franke B, Asherson P, Lichtenstein P, Larsson H. The Familial Co-aggregation of ASD and ADHD: A Register-Based Cohort Study. Molecular Psychiatry. 2018; 23(2): 257–262p.

Butle SR, Gajare SP, Deshpande AP, Bhadane MA. Recent Advances in the Management of Autism: A Review. Inventi Rapid Ethnopharmacology. 2012; 122(11): 7–12p.

Reichenberg C, Boman A, Dalman M, Davidson C, Fruchter M, Hultman E, Lundberg CM, Långström M, Weiser M. Family History of Schizophrenia and Bipolar Disorder as Risk Factors for Autism. Archives of General Psychiatry. 2012; 69(11): 1099–1103p.

Chen X, Guo C, Kong J. Oxidative stress in neurodegenerative diseases. Neural Regen Res. 2012; 7(5): 376–385p. doi: 10.3969/j.issn.1673-5374.2012.05.009. PMID: 25774178; PMCID: PMC43 50122.

Çoğaltay N. Organizational commitment of teachers, A meta-analysis study for the effect of gender and marital status in Turkey. Educational Sciences: Theory & Practice. 2015; 12(25): 15–22p.

Croen LA, Qian Y, Ashwood P, Daniels JL, Fallin D, Schendel D, Schieve LA, Singer AB, Zerbo O. Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development. Autism Research. 2019; 12(1): 123–135p.

Gao Y, Yu Y, Xiao J, Luo J, Zhang Y, Tian Y, Zhang J, Olsen J, Li J, Liew Z. Association of Grandparental and Parental Age at Childbirth with Autism Spectrum Disorder in Children. JAMA Network Open. 2020; 3(4): 202–208p.

Ejlskov L, Wulff JN, Kalkbrenner A, Ladd-Acosta C, Fallin MD, Agerbo E, Mortensen PB, Lee BK, Schendel D. Prediction of Autism Risk from Family Medical History Data Using Machine Learning: A National Cohort Study from Denmark. Biological Psychiatry Global Open Science. 2021; 1(2): 156–164p.

Feldman AL, Johansson AL, Lambert PC, Sieurin J, Yang F, Pedersen NL, Wirdefeldt K. Familial Coaggregation of Alzheimer's Disease and Parkinson's Disease: Systematic Review and Meta-analysis. Neuroepidemiology. 2014; 42(2): 69–80p.

Gitler AD, Dhillon P, Shorter J. Neurodegenerative Disease: Models, Mechanisms, and a New Hope. Disease Models & Mechanisms. 2017; 10(5): 499–502p.

Frans EM, Sandin S, Reichenberg A, Långström N, Lichtenstein P, McGrath JJ, Hultman CM. Autism Risk Across Generations: A Population-Based Study of Advancing Grandpaternal and Paternal Age. JAMA Psychiatry. 2013; 70(5): 516–521p.

Geschwind DH. Advances in Autism. Annual Review of Medicine. 2009; 60: 367–371p.

Ghirardi L, Kuja‐Halkola R, Butwicka A, Martin J, Larsson H, D’Onofrio BM, Lichtenstein P, Taylor MJ. Familial and Genetic Associations between Autism Spectrum Disorder and Other Neurodevelopmental and Psychiatric Disorders. Journal of Child Psychology and Psychiatry. 2021; 62(11): 1274–1282p.

Gopalakrishnan S, Ganeshkumar P. Systematic reviews and meta-analysis: Understanding the best evidence in primary healthcare. Journal of Family Medicine and Primary Care. 2013; 2(1): 9–11p.




DOI: https://doi.org/10.37591/rrjon.v13i2.3272

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Research & Reviews: Journal of Neuroscience

This Journal archive has been shifted to: https://journals.stmjournals.com/archive/rrjons/