A Short Review on Breast Fibroadenomas

Authors

  • Istuti Gupta B.Tech Student, Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut-250005, Uttar Pradesh, India.
  • Sandeep Sirohi Assistant Professor, Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut-250005, Uttar Pradesh, India.
  • Mohammad Munawar Tappa Assistant Professor, Department of Biological and Chemical Engineering, Mekelle Institute of Technology (MIT), Mekelle University, Mekelle-1632, Ethiopia.
  • Surya Prakash DV Assistant Professor, Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut-250005, Uttar Pradesh, India.

Keywords:

Fibroadenoma, benign breast tumor, adolescence, breast lump, breast carcinoma

Abstract

Breast Fibroadenomas are the most common type of benign breast lumps found mainly in adolescent women. These are unilateral, smooth, demarcated, rubbery, mobile, and painless masses. They are believed to be formed by the influence of changes in the female reproductive hormone, estrogen and sometimes the combination of both estrogen and progesterone which mainly occurs at the time of puberty. Fibroadenomas are mostly found in women till the age of 35 and diminish after menopause. They are also influenced by the Body Mass Index (BMI) of an individual and have more chances of occurrence in the ones with a strong medical history of breast lesions or tumors. These are of various types depending on their number, size, texture, etc. Many diagnostic techniques like Mammogram, Magnetic Resonance Imaging (MRI), Pathological Analysis, etc. are used for their evaluation and assessment. Several methods of intervention have been identified and practiced including Surgical Excision, Minimally Invasive Techniques and Ablative Procedures depending on the type of fibroadenoma and some other factors. These benign lumps do not possess any risk of breast carcinoma, however, it has been suggested in several articles that Fibroadenomas might increase the risk of breast cancer in some cases.

References

Salati SA. Breast fibroadenomas: a review in the light of current literature. Pol Przegl Chir 2021; 93 (1): 1-9.

Rihana BP, Rejitha T, Niranjan B. Chances of breast cancer with fibroadenoma-Review. Journal of Scientific and Innovative Research 2017; 6 (2): 84-86.

Maleeha A, Myra K, Kelly VF. Breast fibroadenoma. Statpearls publication 2018.

Fatma S, Imen B, Lamia N, Sadia S, Ines Z, Jamel BH, Tarak BD, Hatem B, Khaled R. Coexistence of invasive ductal breast carcinoma and fibroadenoma. Pan Afr Med J 2019; 33: 139.

Abhinandan G, Hong Z, Jingbai H. The Recent Research and Care of Benign Breast Fibroadenoma. Yangtze Medicine 2019; 3 (2): 135-141.

Shashi PM, Satyendra KT, Manjaree M, Ajay KK. Phyllodes tumor of breast: a review article. ISRN surgery 2013; 1-10.

Aris G, Sofoklis S, Christina G, Eleni C, Spyridon M, Athanasios C, Constantine D, Peter D. A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review. International journal of surgery case reports 2017; 41: 427-430.

Nikhil M, Sumitoj S, Surinder P, Mandeep SS, Ashok K. Bilateral giant juvenile fibroadenoma of the breast. Journal of clinical and diagnostic research 2017; 11(6): 10-12.

Kimberly K, Chandni B, Jason S, Alexander S. Fibroadenoma: from imaging evaluation to treatment. J Am Osteopath CollRadiol 2019; 8: 17-30.

Michelle L, Hooman TS. Breast fibroadenomas in adolescents: current perspectives. Adolescent health, medicine and therapeutics 2015; 6: 159-163.

I-Ching H, Pei-Chen L, Dah-Ching D. Recurrent juvenile fibroadenoma of the breast in an adolescent: A case report. Medicine 2018; 97(20): 1-3.

Asra NS, Julie JR, Eman A, Resha S, Mhd Fayez D, Visakha P, Daniel WV, Sudeshna B, Rouba AF, Michele LC. Breast fibroadenomas are not associated with increased breast cancer risk in an African American contemporary cohort of women with benign breast disease. Breast Cancer Research 2018; 20(1): 1-8.

Sho S, Masayuki Y, Momoko T, Chikashi W, Takeshi M, Kenjiro J, Shin T, Akihiko S, Kaishi S, Akiko MM, Mari K, Nachiko U, Takayuki K. Locally advanced triple-negative breast cancer arising from fibroadenoma with complete response to neoadjuvant chemotherapy: A case report. International journal of surgery case reports 2020; 68: 234-238.

Grace N, Cathleen ON, Rosemary M, Mark C, Paul HR, Linda F, Michael WB, Fionnuala OC, Tara JB. Is excision biopsy of fibroadenomas based solely on size criteria warranted?. The breast journal 2018; 24(6): 981-985.

Alireza N, Atoosa A, Mahshid H, Morteza H. An evaluation of ultrasound features of breast fibroadenoma. Advanced biomedical research 2017; 6: 153-156.

Mingliang Z, Gongjin S, Song Z, Zhen C, Jun Q. Advantages of the modified double-ring areolar incision over the traditional areolar incision in multicentric breast fibroadenoma surgery. Thoracic cancer 2017; 8(5): 423-426.

Jinglin T, Xinmei L, Qiong C. Giant Fibroma of Breast in an Adolescent Female by Inverted "T" Incision: A Case Report and Literature Review. Zhongnan da xuexuebao. Yi xue ban= Journal of Central South University. Medical sciences 2020; 45(2): 204-207.

Onur B, Handan K, Erkin A. Ultrasound-guided therapeutic excisional vacuum-assisted biopsy in breast fibroadenomas. The journal of breast health 2017; 13(2): 74-76.

Mirjam CLP, Muneer A, Sarah EP, Michael D. A review of ablative techniques in the treatment of breast fibroadenomata. Journal of therapeutic ultrasound 2016; 4(1): 1-8.

Wenbin Z, Ruoxi W, Xiaoan L, Lijun L, Mengdi L, Cuiying L, Ge M, Li L, Hong P, Haiyan G, Qiang D, Shui W. Ultrasound-guided microwave ablation: a promising tool in the management of benign breast tumors. International Journal of Hyperthermia 2017; 33(3): 263-270.

Ron Greenberg, MD, Yehuda Skornick, MD and Ofer Kaplan, MD, Management of Breast Fibroadenomas, J Gen Intern Med 1998; 13(9): 640–645.

Dixon JM, Dobie V, Lamb J, et al. Assessment of the acceptability of conservative management fibroadenoma of the breast. Br J Surg. 1996; 83:264–5.

Downloads

Published

2022-07-16

Issue

Vol. 11 No. 2 (2022)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.