Open Access Open Access  Restricted Access Subscription or Fee Access

Analysis of Serum PSA Level and Various Prostatic Pathologies in South-East Rajasthan

Mukesh Vijayvergia, Gulab Kanwar, Imran Hussain, Remesh Kunjunni


Background: Prostate-specific antigen (PSA), an organ-specific tumor marker secreted by the prostate gland exclusively is frequently asked for investigation among men in the second half of life. Although it is a useful marker in carcinoma prostate, simultaneously it is clinically imprecise as benign and malignant lesions, both can have elevated serum levels of PSA. The objective of this research study was to identify whether or not there is a connection in between the degree of prostate-specific antigen in the product and also the histological medical diagnosis of prostatic ailments. Materials and Materials: This research occurred throughout 1 year at the division of Biochemistry at the Government Medical College in Kota and also the accompanying Health centers. In total, 95 situations including prostatic lesions were considered for this investigation. The chemiluminescent immunoassay (CLIA) technique was made use of in order to examine the PSA degrees of these certain patients. The division of pathology at the Government Medical College in Kota did a histopathological analysis of the tissue examples gotten following transurethral resection and core biopsy of the prostate. The H/P of tissues, in addition to their connection to the levels of prostate-specific antigen, were examined. Results: Malignant lesions in the prostate are seen at a higher level of serum PSA; (above 20 ng/ml). Benign prostatic hyperplasia was the most common pathology encountered (n=56; 59%), and serum PSA levels among most of them are below the level of 20 ng/ml. 34 out of 56 patients with BPH are associated with inflammatory pathology along benign hyperplastic pathologies. Both malignant and benign pathologies are seen in men in the 6th and 7th decade of life. Conclusions: Prostatic-specific antigen is an antigen that is just located in prostatic tissue and rises in benign as well as malignant sores of the prostate. But the chances of malignancy are found to increase with the rising values of PSA. Higher levels of serum PSA (>20 ng/ml) are almost associated with prostatic carcinoma. Association of chronic prostatitis with benign prostatic hyperplasia is quite common. Serum PSA level in patients with benign prostatic hyperplasia is below 20 ng/ml (mainly found at a range of 0–10 ng/ml). Elevated serum PSA level in men seeks attention and demands a detailed evaluation. The study had the greatest incidence of benign prostatic hyperplasia, which is one of the most widespread pathological findings.

Full Text:



Balk SP, Ko YJ, Bubley GJ. Biology of prostate-specific antigen. J Clin Oncol. 2003 Jan; 21(2): 383–91. doi:10.1200/JCO.2003.02.083. PMID 12525533.

Hellstrom WJG, editor. Chapter 8: What is the prostate and what is its function?. American Society of Andrology Handbook. San Francisco: American Society of Andrology. 1999. ISBN 978-1- 891276-02-6.

Velonas VM, Woo HH, dos Remedios CG, Assinder SJ. Current status of biomarkers for prostate cancer. Int J Mol Sci. 2013; 14(6): 11034–60. doi:10.3390/ijms140611034. PMC 3709717.

Bid HK, Konwar R, Singh V. Benign prostatic hyperplasia; is it a growing public health concern for India? Indian J Med Sci. 2008; 62(9): 373–4.

Hirachand S, Dangol UMS, Pradhanang S, Acharya S. Study of prostatic pathology and its correlation with prostate-specific antigen. J Pathol Nepal. 2017; 7(1): 1074–1077.

William JC, Deborah SS, Timothy LR, et al. Measurement of a prostatic specific antigen in serum as a screening test for prostatic cancer. N Engl J Med. 1991; 324(17): 1156–61.

Umbehr MH, Gurel B, Murtola TJ, et al. Intraprostatic inflammation is positively associated with serum PSA in men with PSA <4 ng/ml, normal DRE, and negative for prostate cancer. Prostatic Dis. 2005; 18(3): 264–9. 8. Kiehl R, Lemos LD, Stavale JN, Ortiz V. Correlation between histologic grading and serum prostatic specific antigen in prostatic carcinoma. Int Urol Nephrol. 1994; 26: 665–8. Crossref.

Lakhey M, Ghimire R, Shrestha R, Bhatta AD. Correlation of serum-free prostate-specific antigen level with histological findings in patients with prostatic disease. Kathmandu Univ Med J. 2010; 8(30): 158–63. Crossref 10. Josephine A. Clinicopathological study of prostatic biopsies. J Clin Diagn Res. 2014; 8(9): 4–6.

Vani BR, Kumar D, Sharath BN, Murthy VS, Geethamala K. A comprehensive study of prostate pathology in correlation with prostatic specific antigen levels: An Indian study. Clin Cancer Investing J. 2005; 4(5): 617–20.

Banerjee B, Iqbal BM, Kumar H, Kambale T, Bavikar R. Correlation between prostate-specific antigen levels and various prostatic pathologies. J Med Soc. 2016; 30(3): 172–5.

Maru AM, Makwana HH, Lakum NR, Chokshi T, Agnihotri A, Trivedi N, et al. Study on correlation between prostate-specific antigen and various prostatic pathology. Int J Med Sci Public Health. 2014; 3(6): 735–7.

Abdel-Meguid TA, Mosli HA, Al-Maghrabi JA. Prostate inflammation is associated with benign prostatic hyperplasia and prostate cancer. Saudi Med J. 2009; 30(12): 179–83.

Morote-Robles J, Ruibal-Morell A, PalouRedorta J, de Torres-Mateos JA, Soler-Rosello A. Clinical behavior of prostatic specific antigen and prostatic acid phosphatase: A comparative study. Eur Urol. 1988; 14(5): 360–6.

Seamond B, Whitaker B, Yang N, Shaw LM, Aderson K, Bollinger JR. Evaluation of prostate- specific antigen and prostatic acid phosphatase as a prostatic cancer marker. Urology. 1986; 28(6): 472–9.

Dalton DL. Elevated serum prostate-specific antigen due to acute bacterial prostatitis. Urology. 1989; 33(6): 465–70.

Neal DE, Clejan S, Sharma D, Moon TD. Prostate-specific antigen and prostatitis: Effect of prostatitis on serum PSA in the human and nonhuman primate. Prostate. 1992; 20(2): 105–11.

Kohnen PW, Drach GW. The pattern of inflammation in prostatic hyperplasia: a histologic and bacteriologic study. J Urol. 1979; 121(6): 755–60.

Blumenfeld W, Tucci S, Narayan P. Incidental lymphocytic prostatitis: selective involvement with nonmalignant glands. Am J Surg Pathol. 1992; 16(10): 975–81.

Lekili M, Zengin M, Postaci H, Ayder AR. Relationship between histologic grading and serum prostate-specific antigen in prostatic carcinoma. Int Urol Nephrol. 1994; 26: 665–8.

Kamaleshwaran KK, Mittal BR, Harisankar CN, Bhattacharya A, Singh SK, Mandal AK. Predictive value of serum prostate-specific antigen in detecting bone metastasis in prostate cancer patients using bone scintigraphy. Indian J Nucl Med. 2012; 27(2): 81–4.

Albasri A, El-Siddig A, Hussainy A, Mahrous M, Alhosaini AA, Alhujaily A. Histopathologic characterization of prostate diseases in Madinah, Saudi Arabia. Asian Pacific Journal of Cancer Prevention. 2014;15(10):4175-9.



  • There are currently no refbacks.

Copyright (c) 2023 Research & Reviews: Journal of Oncology and Hematology

This Journal archive has been shifted to: