Open Access Open Access  Restricted Access Subscription or Fee Access

Phyto-bioefficiency of Vijaya Extract for Normal Cell Protection and Its Anticancer Efficiency Against Breast Cancer Xenograft

N. Ganesh, Sarfaraz Hanfi, Shivam Chaurasiya, Mahinder Pal, Ankit Jain, Deepti Vats, Dinesh Kumar


Cannabis is an annual, dioecious, flowering herb. Its leaves are palmately compound by serrate leaflets. Cannabis sativa maximum phytochemicals are soluble in organic solvent. The Cannabis plant has been historically used due to its medicinal properties since thousands of years through several beliefs. In India, the department of narcotics has sanction that Cannabis can be grown in a monitored way with proper approval and license. The present study concludes that Cannabis sativa leave’s extracts have cytotoxic effect as some of the column chromatographically isolated fractions (50 mg/ml) show decrease in cell viability by MTT assay. As supporting study, the results of our in vitro investigation suggest that the Cannabis sativa is considered as medicine which is safe for use in humans after other advance confirmative parameters and after proper clinical trials. This work revealed that after further research, cannabis can be useful in certain types of medical conditions, which can lead to the development of various herbal medical cannabis products.

Full Text:



Geoffrey William Guy, Brian Anthony Whittle, Philip Robson. The Medicinal Uses of Cannabis and Cannabinoids. London: Pharmaceutical Press; 2004; 74.

Tomáš Křížek, Miroslava Bursová, Rachel Horsley, Martin Kuchař, Petr Tůma, Radomír Čabala, Tomáš Hložek. Menthol-based hydrophobic deep eutectic solvents: towards greener and efficient extraction of phytocannabinoids. J Clean Prod. 2018; 193: 391–396.

Moliterni VC, Cattivelli L, Ranalli P, Mandolino G. The sexual differentiation of Cannabis sativa L.: A morphological and molecular study. Euphytica. 2004; 140(1–2): 95–106.

Narcotic Drugs. International Narcotics Control Board. 2014; 21p. ISBN 9789210481571.

ElSohly MA. Marijuana and the Cannabinoids. Springer; 2007; 8p. ISBN 978-1-59259-947-9.

Meijer de EPM. Cannabis germplasm resources. In: Ranalli P, editor. Advances in Hemp Research. Binghamton, NY: Haworth Press; 1999; 131–151.

Dana N, Tajaddini MH, Haghjooy JS, Jafari E, Abed A, Jamai M, Vaseghi G. Cannabis sativa extract reduces cytoskeletal associated proteins in breast cancer cell line. Int J Cancer Manag. 2017; 10(5): e5474.

Crime, United Nations Office on Drugs and "Statistical tables". World Drug Report. Vienna, Austria. 2016; p. xiv, 43. ISBN 978-92-1-057862-2. 9. Madane AN, Kamble SK, Patil BJ, Aparadh VT. Assessment of solvent solubility by using phytochemical screen tests of some Euphorbiaceae members. Asian J Pharm Res. 2013; 3(2): 53–55.

Ali Sharif, Muhammad Furqan Akhtar, Bushra Akhtar, Ammara Saleem, Maria Manan, Maryam Shabbir, Muneeb Ashraf, Sohaib Peerzada, Shoaib Ahmed, Moosa Raza. Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay. EXCLI J. 2017; 16: 593–601.

Hussain T, Jeena G, Pitakbut T, Vasilev N, Kayser O. Cannabis sativa research trends, challenges, and new-age perspectives. iScience. 2021 Nov 1; 24(12): 103391.



  • There are currently no refbacks.

Copyright (c) 2023 Research & Reviews: Journal of Oncology and Hematology

This Journal archive has been shifted to: