Open Access Open Access  Restricted Access Subscription or Fee Access

An Essay Discussing Budd-Chiari Syndrome

Keshavamurthy C.D., Saniya Begum Walikar


Budd-Chiari syndrome (BCS) is defined as hepatic venous outflow tract obstruction, independent of the level or mechanism of obstruction, provided the obstruction is not due to cardiac disease, pericardial disease, or sinusoidal obstruction syndrome (veno-occlusive disease). Primary Budd-Chiari syndrome is present when there is obstruction due to a predominantly venous process (thrombosis or phlebitis), whereas secondary Budd-Chiari is present when there is compression or invasion of the hepatic veins and/or the inferior vena cava by a lesion that originates outside of the vein, for example: malignancy. The onset of Budd-Chiari syndrome happens over an extended time, or it occurs very suddenly. Some people with this syndrome have more veins that are affected, or the affected veins are in more difficult areas of the liver; these individuals have more serious form of the syndrome than those with fewer veins impacted in the liver. Budd-Chiari Syndrome is also known as Hepatic Veno-Occlussive Disease, Budd’s Syndrome, and Rokitansky’s Disease.


Budd-Chiari syndrome, hepatomegaly, disorders, abdominal, ascites, thrombosis, sinusoidal obstruction, pericardial disease, veno-occlusive disease, rokitansky’s disease.

Full Text:



Ferral H, Behrens G, Lopera J. Budd-Chiari syndrome. Am J Roentgenol (AJR). 2012 Oct; 199(4): 737–45. doi: 10.2214/AJR.12.9098. PMID: 22997363.

Aydinli M, Bayraktar Y. Budd-Chiari syndrome: etiology, pathogenesis and diagnosis. World J Gastroenterol. 2007 May 21; 13(19): 2693–6. doi: 10.3748/wjg.v13.i19.2693. PMID: 17569137; PMCID: PMC4147117.

Horn Christian L, Amilcar Morales, Savard Christopher E, Farrell Geoffrey C, Ioannou George N. Role of Cholesterol‐Associated Steatohepatitis in the Development of NASH. Hepatol Commun. 2021 Aug 24; 6(1): 12–35.

Babu Lal Meena. (2019 Jan 18). Hepatitis B Infection. [Online]. Icliniq. https://www.icliniq. com/articles/liver-diseases/acute-and-chronic-hepatitis-b-infection.

Michelle Lai (MD, MPH). (2019 Jan 18). Budd Chiari Syndrome. [Online]. [cited on 2023 April 06] Available from: “مدیلیبیلدب م .” MediLib, 2023.

Valla DC. Primary Budd-Chiari syndrome. J Hepatol. 2009 Jan; 50(1): 195–203. doi: 10.1016/j.jhep.2008.10.007. Epub 2008 Oct 26. PMID: 19012988.

Abdel Hameed MR, Elbeih EAS, Abd El-Aziz HM, Afifi OA, Khalaf LMR, Ali Abu Rahma MZ, Sabry A. Epidemiological Characteristics and Etiology of Budd-Chiari Syndrome in Upper Egypt. J Blood Med. 2020 Dec 30; 11: 515–524. doi: 10.2147/JBM.S278678. PMID: 33408545; PMCID: PMC7779296.

Carvalho DT, Oikawa FT, Matsuda NM, Évora PR, Yamada AT. Budd-Chiari syndrome in a 25-year-old woman with Behçet's disease: a case report and review of the literature. J Med Case Rep. 2011; 5(1): 1–4.

Stanciugelu A, Petrică A, Chiriac SD, Iurciuc M, Boruga MV, Balica N, Mederle OA. A rare encounter with two cases of Budd-Chiari syndrome in the Emergency Department: A case report. Exp Ther Med. 2022; 24(6): 1–5.

Denninger MH, Chaït Y, Casadevall N, Hillaire S, Guillin MC, Bezeaud A, Erlinger S, Briere J, Valla D. Cause of portal or hepatic venous thrombosis in adults: the role of multiple concurrent factors. Hepatology. 2000 Mar; 31(3): 587–91. doi: 10.1002/hep.510310307. PMID: 10706547.

Janssen HL, Meinardi JR, Vleggaar FP, van Uum SH, Haagsma EB, van Der Meer FJ, van Hattum J, Chamuleau RA, Adang RP, Vandenbroucke JP, van Hoek B, Rosendaal FR. Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study. Blood. 2000 Oct 1; 96(7): 2364–8. PMID: 11001884.



  • There are currently no refbacks.

Copyright (c) 2023 Research & Reviews: Journal of Oncology and Hematology

This Journal archive has been shifted to: