Open Access Open Access  Restricted Access Subscription or Fee Access

Epidemiology and Clinical Profile of Liver Abscess from a Tertiary Care Hospital in Northern India

Varun Dogra, Ishfaq Ahmad Gilkar, Umer Mushtaq, Irfan Ahmad Mir


Background: Liver abscess is defined as a localized collection of supportive material encapsulated within the liver parenchyma due to inflammatory necrosis secondary to bacterial, amoebic, tubercular, or fungal pathogens. Male gender, advanced age liver cirrhosis, proton pump inhibitors low socioeconomic status, alcoholism, diabetes, immunodeficiency states and poor hygiene are few of the risk factors mentioned in literature that are associated with Liver abscess. In the past decade, the treatment protocol has changed from a radical approach to more conservative approach involving use of antibiotics and percutaneous drainage. Aims and Objectives: We aim to study the epidemiology, clinical profile, laboratory findings and treatment protocol in cases of Liver abscesses in our tertiary care hospital. Materials and Methods: It was a cross sectional observational study conducted in Department of Surgery at Government Medical College, Jammu from January 2018 to December 2020. It consisted of first 150 patients that were admitted to our tertiary care hospital with the diagnosis of Liver Abscess on ultrasonography. Patients were managed either by medical management or surgically via percutaneous aspiration, pigtail drainage or Open/Laparoscopic drainage. Results and Discussion: In this study we found that middle-aged men with low socio-economic status and risk factors of alcoholism and smoking were the most vulnerable group to Pyogenic Liver Abscess. Pain right upper abdomen was the chief complaint in almost all the patients followed by fever, rigors, and chills. Majority of the patients in this study were treated with medical management and only a small proportion of patients required surgical intervention.
Conclusion: Considering the risk factors, there is a need for social awareness in this regard. It is also urged to the general masses regarding the value of good personal hygiene. This study suffers from limitations due to small sample size and limited area coverage.


Pyogenic Liver Abscess, Ultrasonography, Percutaneous Aspiration

Full Text:



Gupta SK, Rasool A, Hela AH, Goel R, Hussain Z. Clinical profile, and management of pyogenic liver abscesses in a tertiary care hospital. Int J Res Med Sci 2020; 8 (1): 52–54.

Adams F. The genuine works of Hippocrates. New York: William Wood and Company, 1886.

Hau T, Haaga JR, Aeder MI. Pathophysiology, diagnosis, and treatment of abdominal abscesses. Curr Probl Surg. 1984 Jul; 21 (7): 1–82

Losie, J.A., Lam, J.C., Gregson, D.B. et al. Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study. BMC Infect Dis 2021: 21 (1), 939.

Soumik Ghosh, Sourabh Sharma, A. K. Gadpayle, H. K. Gupta, R. K. Mahajan, R. Sahoo, Naveen Kumar, "Clinical, Laboratory, and Management Profile in Patients of Liver Abscess from Northern India", Journal of Tropical Medicine, vol. 2014, Article ID 142382, 8 pages, 2014.

Maheshwari T, Kela M, Gupta A, Jain S. Clinical, laboratory and management profile in patients of liver abscess in central India. Int Surg J 2016; 3 (2): 570–7.

Yinnon AM, Hadas-Halpern I, Shapiro M, Hershko C. The changing clinical spectrum of liver abscess: the Jerusalem experience. Postgrad Med J. 1994; 70(824):436–9.

Chen YC, Lin CH, Chang SN, Shi ZY. Epidemiology and clinical outcome of pyogenic liver abscess: an analysis from the National Health Insurance Research Database of Taiwan, 2000-2011. J Microbiol Immunol Infect. 2016 Oct; 49 (5): 646–653. doi: 10.1016/j.jmii.2014.08.028. Epub 2014 Nov 20. PMID: 25442876.

Mangukiya DO, Darshan JR, Kanani VK, Gupta ST. A prospective series case study of pyogenic liver abscess: recent trands in etiology and management. Indian J Surg. 2012 Oct; 74 (5): 385–90. doi: 10.1007/s12262-011-0397-0. Epub 2012 Jan 7. PMID: 24082591; PMCID: PMC3477416.

Perera MR, Kirk A, Noone P. Presentation, diagnosis, and management of liver abscess. Lancet 1980; 2 (8195 pt. 1): 629–32.

Satiani B, Davidson ED. Hepatic abscesses: improvement immortality with early diagnosis and treatment. Am J Surg 1978; 135 (5): 647–50.

Reimar W. Thomsen, Peter Jepsen, Henrik T. Sørensen, Diabetes Mellitus and Pyogenic Liver Abscess: Risk and Prognosis, Clinical Infectious Diseases, 2007:44 (9): 1194–1201.

Mohsen AH, Green ST, Read RC, McKendrick MW. Liver abscess in adults: ten years’ experience in a UK centre. QJM. 2002 Dec; 95 (12): 797–802. doi: 10.1093/qjmed/95.12.797. PMID: 12454322.


  • There are currently no refbacks.

Copyright (c) 2022 Research & Reviews: Journal of Surgery