Brain GST Inhibition, An Additional Mode of Action Following Beta-Cyfluthrin Intoxication in Albino Rat

Authors

  • H.N. Sharma Department of Environmental Toxicology, Dr. B.R. Ambedkar University, Agra, India
  • Amit Kumar Singh Department of Environmental Toxicology, Dr. B.R. Ambedkar University, Agra, India
  • Prabhu N. Saxena Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002 (U.P.), India

DOI:

https://doi.org/10.37591/rrjot.v4i3.1312

Abstract

The aim of the study was to reveal the neurotoxic effect of an orally administered beta-cyfluthrin, a type-II pyrethroid in albino rats on the basis of activity of brain GST (Glutathione-s-transferase), AChE (acetylcholinesterase) and of total proteins level at different doses 35.48 and 5.06, 2.53, 1.68, 1.27 mg/kg body weight, for acute (1 day) and sub-acute (7, 14, 21 and 28 days) treatments respectively. Results reveal that beta-cyfluthrin administration inhibits AChE activity and GST activity, however, no significant effect in total brain proteins could be observed. Affinity towards the hydrophobicity of xenobiotic substance (experimental compound) may lead to an inhibitory mechanism of both AChE and GST levels. Further, imbalance in the neurotransmitter level and alterations in the detoxification mechanism in brain is suggestive of additional mode of action of beta-cyfluthrin other than AChE inhibition.

 

Keywords: Glutathione-s-transferase (GST), acetylcholinesterase (AChE), beta-cyfluthrin, detoxification, albino rats

Downloads

Published

2019-04-08

Issue

Vol. 4 No. 3 (2014)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.