Protective Effect of Epigallocatechin Gallate (EGCG) on Sodium Fluoride (NaF) Induced Changes in Histology of Selected Organs in Rats

Authors

  • S. Thangapandiyan
  • S. Milton Prabu Assistant professor (SG) Department do Zoology, Guindy campus, University of Madras, Chennai

DOI:

https://doi.org/10.37591/rrjot.v3i1.1344

Abstract

Histopathology is the microscopical examination of biological tissues to observe the appearance of diseased cells and tissues in very fine detail. The present study, has been designed to evaluate the effects of oral administration of Sodium Fluoride (NaF) 25 mg/kg/bw (orally), NaF with EGCG (40 mg/kg/bw) daily for four weeks on histological alterations, if any on heart, liver, kidney and testes of rats. Rats were weighed about 160–180 g. NaF alone treated groups showed marked inflammation, necrosis and degenerative changes in the heart, kidney, liver and testes. Treatement with EGCG showed marked improvement in all the degenerative changes inflicted by NaF. Thus, the result of the present study clearly demonstrated that the EGCG due to its free radical scavenging and antioxidant activity, it protects against NaF induced oxidative histopathological changes in the heart, liver, kidney and testes.

 

Keywords: Histopathology, EGCG, NaF, oxidative stress, ROS, histology

Author Biography

S. Milton Prabu, Assistant professor (SG) Department do Zoology, Guindy campus, University of Madras, Chennai

Assistant professor, department of Zoology

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Published

2019-04-10

Issue

Vol. 3 No. 1 (2013)

Section

Research Article

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