Effect of Ethylene Glycol Monomethyl Ether on Testicular Antioxidant System in Adult Rats

Authors

  • Tabarak Malik Assistant Professor Department of Biochemistry, Institute of Health Sciences Jimma University Jimma Ethiopia
  • Ghanshyam Das Gupta

DOI:

https://doi.org/10.37591/rrjot.v3i2.1345

Abstract

Ethylene glycol monomethyl ether (EGME), an environmental contaminant, which is widely used as a solvent especially in lacquers, paints, dyes, pesticides, liquid soap, cleaning solution & cosmetic, chemical intermediates, as a diluent for hydraulic brake fluid etc on industrial scale, has been shown to induce reproductive abnormalities in male rats. The precise nature and mechanism of action of EGME on the male reproductive system is not clear. In the present study, we have sought to investigate the induction of oxidative stress in the testes of rats after exposure to EGME. EGME 2g/kg body weight per day five days in a week was administered dermally to rats for 28 days. The body weight of the animals administered with EGME did not show any significant change. The weight of the testes, epididymis, seminal vesicles, and ventral prostrate decreased significantly. The activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase decreased significantly in the testes of rats treated with EGME. The level of lipid peroxidation increased and glutathione content decreased in the testes of rats treated with EGME. The results suggested that the EGME elicit depletion of antioxidant enzymes and concomitant increase in the level of lipid peroxidation in the testes of rats. In conclusion, the adverse effect of EGME on male reproduction could be due to the induction of oxidative stress in testes.

 

Keywords: Ethylene glycol monomethyl ether, testes, rat, antioxidant enzymes, lipid peroxidation

Downloads

Published

2019-04-10

Issue

Vol. 3 No. 2 (2013)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.