Sub-acute Toxicity of β-cyfluthrin in Hepatic Tissue and its Amelioration through Punica granatum in Swiss albino mice

Abstract

β-cyfluthrin, member of synthetic pyrethroid pesticide Type II is broadly used multipurpose insecticide. Widespread and indiscriminate use of β-cyfluthrin leads to environmental contamination and toxicity towards nontarget mammalian systems. The present study was undertaken to examine toxic manifestation of β-cyfluthrin in hepatic tissue of Swiss albino mice and also evaluate possible mitigative potential of pomegranate juice (PJ) in combating pesticide induced hepato-toxicity. Animals were divided into five groups namely, control, vehicle control, Pomegranate juice (PJ) administered, β-cyfluthrin treated and β-cyfluthrin + Pomegranate juice treated groups. β-cyfluthrin (1/20th of LD₅₀) was administered via feeding canula for 21 days. Significant decrease in body weight and increase in organ weight of animals treated with β-cyfluthrin was observed. Various biochemical indices were studied and results obtained revealed altered protein content, cholesterol content, enzyme associated with energy metabolism (ATPase and SDH), ACPase, ALPase and liver marker enzymes (ALT, AST and γ-GT). Co-administration of PJ along with β-cyfluthrin was able to attenuate altered biochemical parameters effectively. Therefore, it is recommended to people associated occupationally with pesticide manufacturing and utilization to include PJ in their diet so as to prevent harmful toxicological effect on various tissues.

Keywords: β-cyfluthrin, pyrethroid, biochemical parameters, Punica granatum, hepatotoxicity

Cite this Article

S. Pal, P. Vaghela, N. Agravat, H.N. Highland, K.R. Desai. Sub-acute Toxicity of β-cyfluthrin in Hepatic Tissue and its Amelioration through Punica granatum in Swiss albino mice. Research & Reviews: A Journal of Toxicology. 2020; 10(3): 41–52p.