An Overview of the Human Immune Response

Authors

  • PC Kathuria Senior Consultant, Department of Allergy and Asthma Diseases, BLK Superspeciality Hospital & National Allergy Centre, New Delhi, India
  • Manisha Rai Associate Consultant, Department of Allergy and Asthma Diseases, BLK Superspeciality Hospital & National Allergy Centre, New Delhi, India

DOI:

https://doi.org/10.37591/rrjoi.v11i2.2673

Keywords:

Antigen Presenting Cells, Major Histocompatibility Cells, Naïve T cells, Immunoglobulins, Histamine, Inflammatory cells

Abstract

This overview of the immune response provides a glimpse of the complexity of the interactions between the cells and mediators of the immune system. The recognition of the innate immune response by microbes and foreign substances leads to the induction of inflammatory and adaptive immune response. when oxidative stress increases, it affects our vital processes such as glucose homeostasis, cellular life-span and inflammation, which contributes to the pathogenesis of many diseases including atherosclerosis, Ischemic Heart Disease, Diabetes mellitus and neurological disorders, Idiopathic Pulmonary Fibrosis etc. in this review we will focus on mechanism and function of various immune cells, cytokines and Immunoglobulins.

References

Chaplin DD. Overview of the immune response. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S3-S23. doi:10.1016/j.jaci.2009.12.980

Marshall JS, Warrington R, Watson W, Kim HL. An introduction to immunology and immunopathology. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):49. Published 2018 Sep 12. doi:10.1186/s13223-018-0278-1

Maeda K, Caldez MJ, Akira S. Innate immunity in allergy. Allergy. 2019 Sep;74(9):1660-1674. doi: 10.1111/all.13788. Epub 2019 Apr 14. PMID: 30891811; PMCID: PMC6790574.

Aristizábal B, González Á. Innate immune system. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 2.

Murphy KM, Travers P, Walport M. Janeway’s immunobiology. 7th ed. New York: Garland Science; 2007.

Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010;125(Suppl 2):S73–80.

Schroeder HW, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125(Suppl 2):S41–52

Volcheck, Gerald W, Clinical Allergy: Diagnosis and Management, 2009, 1-39

Lockey, R.F., & Ledford, D.K. (Eds.). (2020). Allergens and Allergen Immunotherapy: Subcutaneous, Sublingual, and Oral (6th ed.). CRC Press. https://doi.org/10.1201/9781351208994

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, et al. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563. PMID: 27288833.

Allergen Nomenclature. Bulletin of the World Health Organization, 1994, 72 (5): 797-806

Silvestre MC, Sato MN, Reis VMSD. Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis. An Bras Dermatol. 2018 Mar;93(2):242-250. doi: 10.1590/abd1806-4841.20186340. PMID: 29723367; PMCID: PMC5916398.

Fujiwara N, Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 2005 Jun;4(3):281-6. doi: 10.2174/1568010054022024. PMID: 16101534.

Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. The major histocompatibility complex and its functions. Available from: https://www.ncbi.nlm.nih.gov/books/NBK27156/

Varadé, J., Magadán, S. & González-Fernández, Á. Human immunology and immunotherapy: main achievements and challenges. Cell Mol Immunol 18, 805–828 (2021). https://doi.org/10.1038/s41423-020-00530-6

Kazuhiko Maeda,Matias J. Caldez, Innate immunity in allergy. Allergy. Volume 74, Issue 9 p. 1660-1674

Sosa RA, Forsthuber TG. The critical role of antigen-presentation-induced cytokine crosstalk in the central nervous system in multiple sclerosis and experimental autoimmune encephalomyelitis. J Interferon Cytokine Res. 2011;31(10):753-768. doi:10.1089/jir.2011.0052

Eldanasory OA, Eljaaly K, Memish ZA, Al-Tawfiq JA. Histamine release theory and roles of antihistamine in the treatment of cytokines storm of COVID-19. Travel Med Infect Dis. 2020;37:101874. doi:10.1016/j.tmaid.2020.101874

Wang, B., Wu, L., Chen, J. et al. Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Sig Transduct Target Ther 6, 94 (2021).

Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 2011;31(5):986-1000. doi:10.1161/ATVBAHA.110.207449

Cuzzo B, Lappin SL. Physiology, Leukotrienes. [Updated 2020 Sep 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526114/

Akdis CA, Arkwright PD, Brüggen MC, Busse W, Gadina M, Guttman-Yassky E, Kabashima K, Mitamura Y, Vian L, Wu J, Palomares O. Type 2 immunity in the skin and lungs. Allergy. 2020 Jul;75(7):1582-1605. doi: 10.1111/all.14318. Epub 2020 May 10. PMID: 32319104.

Urb M, Sheppard DC. The role of mast cells in the defence against pathogens. PLoS Pathog. 2012;8(4):e1002619. doi:10.1371/journal.ppat.1002619

Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt. Roitt's Essential Immunology, 13th Edition. Wiley-Blackwell; January 2017

Schroeder HW Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S41-S52. doi:10.1016/j.jaci.2009.09.046]

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Published

2021-10-04

Issue

Vol. 11 No. 2 (2021)

Section

Review Article

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