To Study Prevalence of Celiac Disease in Chronic Diarrhoea Patients in North India Region

Authors

  • Sanjeev Thakral Department of Medicine, Department of Medicine, NIMS Medical College, Jaipur, Rajasthan, India
  • Mahesh Kumar Gupta Department of Medicine, Department of Medicine, NIMS Medical College, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.37591/rrjom.v5i1.1489

Abstract

 

Celiac disease (CD) is a disorder of an inflammatory T-cell response to the proteins called “gluten” and characterized by the presence of typical auto antibodies and histological alterations of the small bowel mucosa. It is a common but frequently unrecognized disease. To study the prevalence of celiac disease in chronic diarrhoea patients in north India region and study the effects of gluten free diet in these patients clinically, serologically and by histopathology of endoscopic biopsy tissue. Total 120 cases were selected who having diarrhea of more than two weeks duration were enrolled in the study. All the patients having clinical suspicion would be subjected to following special investigations beside the routine investigations like stool examination done for pH, presence of fecal reducing substances (Benedict's test), occult blood (Benzidine test), microscopy and cultured. Anti - IgA TTG antibodies were assessed by indirect solid Phase immunometric assay (ELISA). Patients with positive anti-IgA tTG, whose parents provided consent, underwent upper GI endoscopy under topical anesthesia. Four biopsies were taken from the second portion of the duodenum and histopathological grading done according to a modification of the Marsh classification. The prevalence of celiac disease is upcoming in our country also and it is around 10% in this study of chronic diarrhoea. In the country like ours where endoscopic biopsy not easily available in remote hospitals, patients with high index of clinical suspicion and higher Anti tTG titer must be subjected for the gluten free diet.

 

Keywords: Celiac disease, Chronic diarrhoea, Gluten

Cite this Article

Mahesh Kumar Gupta, Sanjeev Thakral, To Study Prevalence of Celiac Disease in Chronic Diarrhoea Patients in North India Region; Research & Reviews: Journal of Medicine 2015; 5(1): 27–30p.


Downloads

Published

2019-05-01

Issue

Vol. 5 No. 1 (2015)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.