Histological and Functional Effect of Melatonin on Reproductive System

Authors

  • Mahari Geretsadkan Meles Mahari Geretsadkan Meles, BSc, MSc, Lecturer Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, College of Health Sciences, Mekelle University-Mekelle, Ethiopia, Email: [email protected], phone no: +251 99877784, Fax +251 344416681, P. O. Box 1871
  • Hafte Assefa Beyene

DOI:

https://doi.org/10.37591/rrjomst.v9i1.1789

Keywords:

Antral follicles, Corpora lutea, Melatonin, Ovaries, Spermatogenesis, Testes

Abstract

Many experimental studies reported that melatonin has shown to induce reproductive toxicity. The purpose of this review is to discuss the evidence regarding the toxic effect of melatonin on the reproductive system and its possible mechanism of toxicity. Literature included in thisreview showed that an extrinsic dose of melatonin inducespharmaceutical, biochemical and physiological effects on the mammalian reproductive function. Empirical and histological examination of melatonin exposure on reproductive function has shown inhibited spermatogenesis, obstruction in tubular lumen and decrease in absolute and relative testicular weight, size, serum testosterone concentration and sperm of experimental animals. Though exposure to melatonin has shown no significant difference in ovarian volume and relative ovarian weights, various studies reviewed in the present article reported that exposure to melatonin revealed to have a higher number of primordial follicles, primary and secondary follicles and antral follicles. Additionally, studies reported that in the 90-day-old ovary of the melatonin exposed mice, there was almost double the number of corpora lutea as compared to controls. Furthermore, exposure to melatonin has shown to induce cellular toxicity in the testesand ovaries at the higher dose.

 

Keywords: Antral follicles, Corpora lutea, melatonin, ovaries, spermatogenesis, testes

 

Cite this Article

Mahari Geretsadkan Meles, Hafte Assefa Beyene. Histological and Functional Effect of Melatonin on Reproductive System. Research & Reviews: Journal of Medical Science and Technology. 2020; 9(1):
16–23p.


Downloads

Published

2020-05-18

Issue

Vol. 9 No. 1 (2020)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.