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Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Depression and Perception of Burden of a Couple with a Cerebral Palsy Child

Gangotri Borah, Monalisa Pattnaik

Abstract


Aim: To determine effect of rTMS on depression on a couple with Cerebral Palsy Child. Purpose: Parenting children with neurodevelopmental disorder is related to a higher rate of depression and anxiety, increased stress, and reduced quality of life for parents and adversely affects functioning of the parents and also hampers the quality of care being provided to the CP child. Studies have shown positive effect of rTMS on depression but fewer studies till date to see long term effect of rTMS. Methodology: A parent couple to a CP child (spastic diplegic) was selected for the study using Non- Probabilistic (Purposive) sampling. They were assessed for burden using Caregiver Burden Scale (CBS) and depression using Beck's Depression Inventory II (BDI II) and Patient Health Questionnaire (PHQ-9) at different time periods: consecutive 5 days prior to treatment, after 28 days of treatment for 5 consecutive days to see immediate effect and post 1 month after cessation of treatment for 5 consecutive days to see the carry over effect. Two Standard Deviation band method (Shewhart chart) was used for data analysis. Results: The results showed that for Subject 1 BDI II and PHQ-9 and for Subject 2 BDI II, PHQ-9 and CBS scores had all the post intervention points fall outside the 2-SD band which was statistically significant (p<0.05) and scores after cessation of treatment for 1 month were significantly less in comparison to pre scores whereas it is not significantly different from post intervention scores suggesting that there is immediate and carry over effect of rTMS on depression (Subject 1 and 2) and burden (Subject 2). Conclusion: Repetitive transcranial magnetic stimulation (rTMS) has significant effect in reducing depression and has a significant carryover effect and also reduces perception of burden to certain extent.

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References


Oskoui M, Coutinho F, Dykeman J, et al. An update on the prevalence of cerebral palsy:a systematic review and meta-analysis. Dev Med Child Neurol. 2013; 55(6): 509–19.

McIntyre S, Taitz D, Keogh J, et al. A systematic review of risk factors for cerebral palsy in children born at term in developed countries. Dev Med Child Neurol. 2013; 55(6): 499–508.

Bottcher L. Children with spastic cerebral palsy, their cognitive functioning, and social participation: a review. Child Neuropsychol. 2010; 16(3): 209–28.

Mausbach BT, Chattillion EA, Roepke SK, et al. A comparison of psychosocial outcomes in elderly Alzheimer caregivers and noncaregivers. Am J Geriatr Psychiatry. 2013; 21(5): 5–13.

Grootenhuis MA, Bronner MB. Paediatric illness! family matters. Acta Paediatr. 2009; 98(6): 940–1.

Parkes J, Caravale B, Marcelli M, Franco F, Colver A. Parenting stress and children with cerebral palsy: A European cross-sectional survey. Dev Med Child Neurol. 2011; 53(9): 815–821.

Carnevale FA, Rehm RS, Kirk S, McKeever P. What we know (and do not know) about raising children with complex continuing care needs. J Child Health Care. 2008; 12(1): 4–6.

Thrush A, Hyder AA. The neglected burden of caregiving in low- and middle-income countries. Disabil Health J. 2014; 7(3): 262–272.

Thurston S, Paul L, Loney P, Ye C, Wong M, Browne G. Associations and costs of parental symptoms of psychiatric distress in a multi-diagnosis group of children with special needs. J Intellect Disabil Res. 2011; 55(3): 263–280.

Rahman A, Harrington R, Bunn J. Can maternal depression increase infant risk of illness and growth impairment in developing countries? Child Care Health Dev. 2002; 28(1): 51–56.

Majnemer A, Shevell M, Rosenbaum P, Law M, Poulin C. Determinants of life quality in school- age children with cerebral palsy. J Pediatr. 2007; 151(5): 470–475, 475.e1–3.

Janicak PG, OReardon JP, Sampson SM, et al. Transcranial magnetic stimulation in the treatment of major depressive disorder: a comprehensive summary of safety experience from acute exposure,extended exposure, and during reintroduction treatment. J Clin Psychiatry. 2008; 69(2): 222–232. DOI: 10.408/JCP.v69n0208

Salomons TV, Dunlop K, Kennedy SH, et al. Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder. Neuropsychopharmacology. 2014; 39(2): 488–498. DOI: 10.1038/np.2013.2

Liston C, Chen AC, Zebley BD, et al. Default mode network mechanisms of transcranial magnetic stimulation in depression. Biol Psychiatry. 2014; 76(7): 517–526. DOI: 10.1016/j.biopsych.2014.01.023 15. Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985; 1(8437): 1106–1107. DOI: 10.1016/S0140-6736(85)92413-4

Gao L, Cai Y, Wang H, Wang G, Zhang Q, Yan X. Probing prefrontal cortex hemodynamic alterations during facial emotion recognition for major depression disorder through functional near- infrared spectroscopy. J Neural Eng. 2019; 16(2): 026026. doi:10.1088/1741-2552/ab0093.

Noda Y, Zomorrodi R, Vila-Rodríguez F, Downar J, Farzan F, Cash RF, Rajji TK, Daskalakis ZJ, Blumberger DM. Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation. Depress Anxiety. 2018; 35(5): 448–456. doi: 10.1002/da.22738.

Aoki R, Sato H, Katura T, Matsuda R, Koizumi H. Correlation between prefrontal cortex activity during working memory tasks and natural mood independent of personality effects: An optical topography study. Psychiatry Res Neuroimaging. 2013; 212(1): 79–87. doi: 10.1016/j.pscychresns.2012.10.009.

Aoki R, Sato H, Katura T, Utsugi K, Koizumi H, Matsuda R, Maki A. Relationship of negative mood with prefrontal cortex activity during working memory tasks: An optical topography study. Neurosci Res. 2011; 70(2): 189–196. doi: 10.1016/j.neures.2011.02.011.

Compare A, Brugnera A, Adorni R, Sakatani K. Effects of Positive and Negative Mood Induction on the Prefrontal Cortex Activity Measured by Near Infrared Spectroscopy. Adv Exp Med Biol. 2016; 923: 151–157.

Siegle GJ, Steinhauer SR, Thase ME, Stenger V, Carter CS. Cant shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry. 2002; 51(9): 693–707. doi: 10.1016/S0006-3223(02)01314-8.

Janicak PG, Dokucu ME. Transcranial magnetic stimulation for the treatment of major depression. Neuropsychiatr Dis Treat. 2015; 11: 1549–1560.

George MS, Taylor JJ, Short EB. The expanding evidence base for rTMS treatment of depression. Curr Opin Psychiatry. 2013; 26(1): 13–18. 24. Ishida FA, Kobayashi A, Hu A, Yamaguchi T,Watahiki H, Kobayashi H. A case study: the effect of transcranial magnetic stimulation (TMS) on stress levels, quality of sleep, and the autonomic nervous system. Adv Clin Transl Res. 2018; 2: 100004. https://pdfs.semanticscholar.org/0967/027f34c6824c44e9a697be3be5b333687617.pdf

Perera T, George MS, Grammer G, Janicak PG, Pascual-Leone A, Wirecki TS. The Clinical TMS Society consensus review and treatment recommendations for TMS therapy for major depressive disorder. Brain Stimul. 2016; 9(3): 336–346.

Roth Y, Amir A, Levkovitz Y, Zangen A. Three-dimensional distribution of the electric field induced in the brain by transcranial magnetic stimulation using figure-8 and deep H-coils. J Clin Neurophysiol. 2007; 24(1): 31–38.

Demitrack MA, Thase ME. Clinical significance of transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant depression: synthesis of recent data. Psychopharmacol Bull. 2009; 42(2): 5–38. https://www.researchgate.net/profile/Mark_Demitrack/publication/26692296_Clinical_Significance_of_Transcranial_Magnetic_Stimulation_TMS_in_the_Treatment_of_Phar macore sistant_Depression_Synthesis_of_Recent_Data/links/54ecd7220cf28f3e6534e2be.pdf

Connolly KR, Helmer A, Cristancho MA,Cristancho P, OReardon JP. Effectiveness of transcranial magnetic stimulation in clinical practice post-FDA approval in the United States: results observed with the first 100 consecutive cases of depression at an academic medical center. J Clin Psychiatry. 2012; 73(4): 567–573.

Shinba T, Kariya N, Matsuda S, Matsuda H, Obara Y. Increase of frontal cerebral blood volume during transcranial magnetic stimulation in depression is related to treatment effectiveness: a pilot study with near-infrared spectroscopy. Psychiatry Clin Neurosci. 2018; 72(8): 602–610. 30. Richieri R, Boyer L, Farisse J, Colavolpe C, Mundler O, Lancon C, Guedj E. Predictive value of brain perfusion SPECT for rTMS response in pharmacoresistant depression. Eur J Nucl Med Mol imaging. 2011; 38(9): 1715–1722.

Nahas Z, Teneback CC, Kozel A, et al. Brain effects of TMS delivered over prefrontal cortex in depressed adults: role of stimulation frequency and coil-cortex distance. J Neuropsychiatry Clin Neurosci. 2001; 13(4): 459–470.

Baeken C, De Raedt R. Neurobiological mechanisms of repetitive Transcranial magnetic stimulation on the underlying neurocircuitry in unipolar depression. Dialogues Clin Neurosci. 2011; 13(1): 139–45.




DOI: https://doi.org/10.37591/rrjos.v11i3.3084

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