An Overall Assessment of Psoriasis

Authors

  • Gyanendra kumar Gupta
  • Gagan Devi

Keywords:

Psoriasis, National Psoriasis Foundation, Monozygotic twins, Dizygotic twins and Genetic.

Abstract

Psoriasis has an equal impact on both genders and can manifest at any age, although it typically appears more frequently between the ages of 15 and 25 years. In Western populations, it is estimated that around 2% to 3% of individuals experience psoriasis. Among the 7.5 million individuals registered with general practitioners in the United Kingdom, the prevalence was found to be 1.5%. According to a survey carried out by the National Psoriasis Foundation in the United States, the occurrence of psoriasis among adult Americans was found to be 2.1%. Within this study, it was discovered that 35% of people with psoriasis could be categorized as having moderate to severe symptoms. Around one out of three individuals with psoriasis have a familial background of the condition, and researchers have identified specific genetic regions linked to its onset. Studies on identical twins suggest a 70% likelihood of the other twin developing psoriasis if one twin already has it. This indicates a concordance rate of around 20% for fraternal twins. These discoveries indicate that both genetic susceptibility and environmental elements play a role in the emergence of psoriasis.

References

Shah SN. API text book of medicine, 7th edition. Mumbai, India: The Association of Physicians of India; 2022. [Online] Available at https://www.apiindia.org/Editor-In-Chief--API-Text-Book-Of- Medicine-7th-Edition [Accessed on July 2023]

Mohan H. Textbook of pathology. New Delhi, India: Jaypee Publishers; 2005. [Online] Available at https://www.jaypeedigital.com/book/9788180613685 [Accessed on July 2023]

Sembulingam K, Sembulingam P. Essentials of medical physiology. New Delhi, India: Jaypee Brothers Publishers; 2012. [Online] Available at https://e-library.sammu.uz/en/book/25 [Accessed on July 2023]

Gupta R. Textbook of dermatology. New Delhi, India: Jaypee Brothers Publishers; 2003. [Online] Available at https://ortholibrary.in/eReader/chapter/9788180610349/preliminary [Accessed on July 2023]

Shegal VN. Textbook of clinical dermatology, 5th edition. New Delhi, India: Jaypee Publishers; 2023. [Online] Available at https://www.scribd.com/doc/226158693/VN-Shegal-Textbook-of- Clinical-Dermatology-5th-Edition [Accessed on July 2023]

Haycox CL. Rook’s textbook of dermatology: CD-ROM. 1997; 3 (2). [Online] Available at https://escholarship.org/uc/item/3pg4f1vv [Accessed on July 2023]

World Health Organization. (2016). Global report on PSORIASIS [Online] Available at https://apps.who.int/iris/bitstream/handle/10665/204417/9789241565189_eng.pdf.psoriasis?seque nce=1 [Accessed on July 2023]

Papp KA, Gniadecki R, Beecker J, Dutz J, Gooderham MJ, Hong CH et al. Psoriasis prevalence and severity by expert elicitation. Dermatol Ther. 2021; 11: 1053–1064.

Biogen. (2003). FDA Approves Biogen’s Amevive(r) for treatment of psoriasis. [Online] Newswise.com. Available at https://www.newswise.com/articles/fda-approves-biogens-ameviver- for-treatment-of-psoriasis [Accessed on July 2023]

Zhang KX, Ouellette BF. CAERUS: predicting CAncER oUtcomeS using relationship between protein structural information, protein networks, gene expression data, and mutation data. PLoS Comput Biol. 2011; 7 (3): e1001114.

Published

2023-07-25

Issue

Section

Review Article