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Qurs-e-Kaknaj: An Effective Unani Compound Drug in Treatment of Lower Urinary Tract Symptoms (LUTS)

Imtiyaz Ahmed, Iqbal Aziz, Gufran Ahmad

Abstract


Lower urinary tract symptom is a common presentation among elderly male patients and required a safe pharmacological composition to improve the quality of life in these patients. In recent years, there has been a shift in paradigm of medicine selection from synthetic to herbal medicine. Medicinal plants have been used in Unani System of Medicine since antiquity to treat ailments as rich source of therapeutic agent. Qurs-e-Kaknaj is a Unani herbal compound formulation to treat various urinary tract symptoms and has significant improvement in increased frequency of micturition, suprapubic discomfort and burning. In the present drug review, composition, pharmacological properties and chemical constituents present in Qurs-e-Kaknaj are discussed in detail.


Keywords


lower urinary tract symptom (LUTS), Unani System of Medicine, Qurs-e-Kaknaj

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References


Ahmad G, Ahmad W, Khan NA, Ahmad S. Evaluation of diuretic activity of ethanolic extract of Habb-e-Kaknaj (Physalis alkekengi, Linn Fruit) in rats. Hippocratic Journal of Unani Medicine. 2019; 8(3): 1–9p.

Sanchooli N. Antidiabetic Properties of Physalis alkekengi Extract in Alloxan-Induced Diabetic Rats. Res J Pha Biol Chem Sci. 2011; 12(2): 168–173p.

Ibironke GF, Ajiboye KI. Studies on the antiinflammatory and analgesic properties of Chenopodium ambrosiodies leaf extract in rats. Int J Pharmacology. 2007; 13(3): 111–115p.

Mohammad K, Gharib N, Maryam M, Zahra G, Naseri D. Antispasmodic effect of Physalis alkekengi fruit extract on rat uterus. Iran J Reprod Med. 2008; 6(4):193–198p.

Qarabaadeen-e-Majeedi. Daftar Jamia Tibbiya. Delhi, India: Ala Printing Press. 235p.

Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The Unani Pharmacopoeia of India, Part-I Volume-I. New Delhi, India: Ministry of Health & Family Welfare, Government of India; 1998. 9–10p.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: Council of Scientific & Industrial Research; 1996. 2p, 14p, 72p, 83p, 126p, 202p, 249p.

Singh VK, Khan AM. Medicinal plants and folklores: A strategy towards conquest, Vol. 9 (Glimpses in Plant Research). New Delhi, India: Krieger Publication Co.; 1990. 17p, 80p, 95p.

Kirtikar KR, Basu BD. Indian Medicinal Plants, Vol. 1. Allahabad, India Bishen Singh Mahendra Pal Singh; 1981. 126p, 214p, 215p, 242p, 296p, 300p, 301p, 727p, 728p.

Kataria R, Hemraj, Singh G, Gupta A, Jalhan S, Jindal A. Pharmacological activities on Glycyrrhiza Glabra–A Review. Asian Journal of Pharmaceutical and Clinical Research. 2013; 6(Suppl 1): 5–7p.

Sharma V, Agrawal RC. Glycyrrhiza glabra-A Plant for the Future. Mintage Journal of Pharmaceutical & Medical Sciences. 2013; 2(3): 15–20p.

Sharma V, Agrawal RC, Pandey S. Phytochemical screening and determination of anti-bacterial and anti-oxidant potential of Glycyrrhiza Glabra root extracts. Journal of Environmental Research and Development. 2013; 7(4): 1552–1558p.

Hikino H, Wagner H, Farnsworth NR, editors. Recent research on oriental medicinal plants, Economic and medicinal plant research. London: Academic Press; 1985. 53–85p.

Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The Unani Pharmacopoeia of India, Part-I Volume-II. New Delhi, India: Ministry of Health & Family Welfare, Government of India; 2016. 27–28p, 65–66p.

CCRUM. Standardization of Single Drugs of Unani Medicine, Part-III. New Delhi, India: JM Jaina Books; 1997. 46–50p.

Chatterjee A, Pakrashi SC. The Treatise on Indian Medicinal Plants, Vol. 2. New Delhi, India: Publications & Information Directorate; 1992. 10–11p, 51–52p.

Ali Esmail Al-Snafi. The medical importance of Cydonia oblonga—A review. IOSR Journal of Pharmacy. 2016; 6(6): 87–99p.

Silva FG, Oliveira GL. Popular knowledge and antimicrobial activity of Cydonia oblonga Mill. (Rosaceae). Rev Bras Plantas Med. 2013; 15(1): 98–103p.

Essafi-Benkhadir, K., Refai, A., Riahi, I., Fattouch, S., Karoui, H. and Essafi, M., 2012. Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition. Biochemical and biophysical research communications, 418(1), pp.180-185.

Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The Unani Pharmacopoeia of India, Part-I Volume-III. New Delhi, India: Ministry of Health & Family Welfare, Government of India; 2001. 47–49p.

Razavi SM, Zarrini G, Molavi G, Ghasemi G. Bioactivity of Malva Sylvestris L., A Medicinal Plant from Iran. Iranian Journal of Basic Medical Sciences. 2011; 14(6): 574–579p.

Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The Unani Pharmacopoeia of India, Part-I Volume-IV. New Delhi, India: Ministry of Health & Family Welfare, Government of India; 2006. 80–82p.

CCRUM. Standardization of Single Drugs of Unani Medicine, Part-I. New Delhi, India: JM Jaina Books; 1987. 166–169p, 179–185p.

Elkhayat ES, Ibrahim SRM, Aziz MA. Portulene, A new diterpene from Portulaca oleracea L. Journal of Asian Natural Products Research. 2008; 10(11–12): 1039–1043p.

Lee AS, Kim JS, Lee YJ, Kang DG, Lee HS. Anti-TNF-

Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology, 11th Edition. USA: McGraw-Hill Education; 2009.

Evans WC, editor. Trease ans Evans Pharmacognosy. 16th edition. London: Saunders publishing Inc.; 2007.

Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The Unani Pharmacopoeia of India, Part-I Volume-V. New Delhi, India: Ministry of Health & Family Welfare, Government of India; 2008. 40–41p, 99–100p.

Rezaei M, Dadgar Z, Zadeh AN, Alireza S, Namin M, Pakzad I, Davodian E. Evaluation of the antibacterial activity of the Althaea officinalis L. leaf extract and its wound healing potency in the rat model of excision wound creation. Avicenna J Phytomed. 2014; 5(2): 501–551p.

Chatterjee A, Pakrashi SC. The Treatise on Indian Medicinal Plants, Vol. 4. New Delhi, India: Publications & Information Directorate; 1995. 190–191p.

Moniruzzaman M, Bose S, Kim YM, Chin YW, Cho J. The ethyl acetate fraction from Physalis alkekengi inhibits LPS induced Pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology. 2016; 4(2): 26–36p.

Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH). The Unani Pharmacopoeia of India, Part-I Volume-VI. New Delhi, india: Ministry of Health & Family Welfare, Government of India; 2016. 38–39p, 48–49p, 52–53p.

Bai AJ, Rai RV, Samaga PV. Evaluation of the antimicrobial activity of three medicinal plants of South India. Malaysian Journal of Microbiology. 2011; 7(1): 14–18p.

Goud PSP, Murthy KSR, Pullaiah T, Babu GVAK. Screening for antibacterial and antifungal activity of some medicinal plants of Nallamalais, Andhra Pradesh, India. Journal of Economic and Taxonomic Botany. 2005; 29: 704–708p.

Safiuddin SA. Unani Advia-e-Mufrada. New Delhi, India: NCPUL; 1986. 69p, 144–145p.

Kabeeruddin H. Makhzan-ul-Mufradat Al-Maroof Khawas-ul-Advia. Jama Masjid, Delhi: Matia Mahal; YNM. 120p, 265–266p.

Banso A. Phytochemical and antibacterial investigation of bark extracts of Acacia nilotica. J Med Plants Res. 2009; 3: 82–85p.

Kalaivani T, Mathew L. Free radical scavenging activity from leaves of Acacia nilotica (L.) Wil. ex Delile, an Indian medicinal tree. Food Chem Toxicol. 2010; 48: 298–305p.

Gill NS, Bajwa J, Sharma P, Dhiman K, Sood S, Sharma PD, Singh B and Bali M. Evaluation of therapeutic potential of traditionally consumed Cucumis melo seeds. Asian Journal of Plant Sciences. 2011; 10(1): 86–91p.

Wright CI, Van-Buren L, Kroner CI, Koning MM. Herbal medicines as diuretics: A review of the scientific evidence. J Ethnopharmacol. 2007; 114(1): 1–31p.

Kamarudin EZ, Ahmed Q, Helaluddin ABM, Nazren Z, Sirajudin M, Ahmad Chowdhury AJK. Studies on bactericidal efficacy of pumpkin (Cucurbita moschata Duchesne) peel. Journal of Coastal Life Medicine. 2014; 2(2): 146–153p.

Kirtikar KR, Basu BD. Indian Medicinal Plants, Vol. IV. Allahabad, India: Lalit Mohan Basu; 1981. 2700p, 2701p.

Chalise U. The Poppy Plant: Phytochemistry & Pharmacology. Indo Global Journal of Pharmaceutical Sciences. 2015; 5(1): 58–65p.

Ahmed I, Aziz I, Ahmad G. Effects of Qurs-e-Kaknaj on lower urinary tract symptoms (LUTS) & uroflowmetric parameters. Int J Health Sci Res. 2019; 9(8): 248–253p.


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