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A Clinical Study on Itrifal Shahatra and Sharbat Unnab to Evaluate the Mechanisms of Action and Unani Principles in Buthūr (Acne)

Md Manzar Alam, Mahboob Ussalam, Anirban Goswami, Md Ishtiyaque Alam, Mumtaz Ahmad, Rajesh ., Md Hashmat Imam, Shaista Bano


The current study assesses the possible mechanisms of action of Itrifal shahatra and sharbat unnab in Buthūr (Acne) with the support of Unani principles and evidence of the trial. The skin eruptions like macules, papules and pastules are described in the Unani classical literature as Buthūr. The main cause of Buthūr is khilt e Raddi (Morbid Humour) due to derangement of Akhlat (body humor). Musaffi-e-khoon (Blood purifier), Muhallil-e-auram (anti-inflammatory), Dāfi‘-i-Ta‘affun (anti-septic/antibiotic) and Moaddilat-e-dam (alterative) are used in Unani System of Medicine for the management of Buthūr. Several clinical studies support this trial. There is a need to develop different therapeutic options for the treatment of Buthūr-e-Jild with possible mechanisms of action according to Unani principles.  An open level study was conducted in RRIUM, Patna, Bihar for a period of 2 years. 128 subjects were randomly selected; among them, 100 cases completed the course of study. All the subjects were given Sharbat e Unnab 20ml and Itrifal Shahatra 5 grams twice a day for three weeks. The levels of improvements were recorded in terms of percentage efficacy as calculated from improvement in the signs and symptoms in the visual analog scale. The results were statistically analyzed and it showed that the Unani Pharmacopoeial formulations Sharbat-e-Unnab and Itrifal shahtra were significantly effective in the management of Buthūr and possible mechanisms of action are also evaluated.


Buthūr, Sharbat Unnab, Itrifal Shahatra, Acne, Unani Medicine

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Ahmed, Khawaja Rizwan, Tarjuma Sharah Asbab published by CCRUM, New Delhi, Department of A YUSH, Ministry of H&FW, Govt. of India: 2010, 261.

Ahsanullah, Moalijat-i-Amraz-i-jild-wa-mafasil, Maktaba Al Hijaz, Lucknow,

140, 147-149.

Arzanl, Hakim Muhammad Akbar, Tibb-i-Akbar, Urdu Translation by AllamaHakTm Muhammad Husayn, Faisal Publications, Deoband (U.P.), 2003, 615-616,630.

Anonymous. National Formulary of Unani Medicine Part-I CCRUM, Ministry of Health and Family Welfare, Govt. of India, New Delhi, 2008, 96, 224.

Hakeem Muhammad Kabiruddin1977 “Shaukat Book Depot Shaukat Bazar, Gujrat ,pp-8, Fifth Edition

Allama Hakeem Najmulghani “ Khazayn-al-advia” Idara kitab al shifa, New Delhi. 950-952.

Ibn-e-Betar “Al Jame Al-Mufridat-Al-advia wa Al-Aghzia” Central Council for Research in Unani Medicine, Deptt. of AYUSH, Ministry of Health and Family welfare, Govt. of India, New Delhi, Vol-III, 1999, 314-316,

Gao QH, Wu CS, Wang M. The jujube (Ziziphus jujuba Mill.) fruit: A review of current knowledge of fruit composition and health benefits. J Agric Food Chem 2013; 61:3351‑63.

Al-Reza, S.M., Rahman, A., Lee, J.H., Kang, S.C., Potential roles of essential oil and organic extracts of Zizyphus jujuba in inhibiting food-borne pathogens. Food Chem. 2010, (119) 981–986.

Fan YM, Xu LZ, Gao J, Wang Y, Tang XH, Zhao XN, et al.Phytochemical and antiinflammatory studies onTerminalia catappa. Fitoterapia 2004; 75:253-60.

Gbaguidi F, Accrombessi G, Moudachirou M, Quetin-Leclercq J. HPLC quantification of two isomeric triterpenic acids isolated from Mitracarpus scaber and antimicrobial activity on Dermatophilus congolensis. J Pharm Biomed Anal 2005; 39:990-5.

Liu Y, Hartley DP, Liu J. Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein. Toxicol Lett 1998; 95:77-85.

Kalogeropoulos N, ChiouA, Ioannou M, Karathanos VT, Hassapidou M, Andrikopoulos NK. Nutritional evaluation and bioactive microconstituents (phytosterols, tocopherols, polyphenols, triterpenic acids) in cooked dry legumes usually consumed in the Mediterranean countries. Food Chem 2010;121:682-90.

Asma, H.S., Moza, T.H.G., Hossain, M.A., 2017. Brine shrimp toxicity of various polarities leaves and fruits crude fractions of Ziziphus jujuba native to Oman and their antimicrobial potency. Sust. Chem. Pharm. 5, 122–125.

Romero C, García A, Medina E, Ruíz-Méndez V, Castro A, Brenes M. Triterpenic acids in table olives. Food Chem 2010;118:670-4.

Guo S, Duan JA, Tang Y, Su S, Shang E, Ni S, et al. High-performance liquid chromatography--Two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis. J Pharm Biomed Anal 2009; 49:1296-302.

L.Y.W. Huang, B. Cai, D. Li, J. Liu and M. Liu. A preliminary study on the pharmacology of the compound prescription huangqin tang and its component drugs. Zhongguo Zhong Yao Za Zhi. 1990,15: 115­128

B.N.C.M. Su, N.R. Farnsworth, H.H. Fong, J.M. Pezzuto and A.D. Kinghorn. Activity­guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase­2 inhibitory assay. Planta Med. 68: 1125­1128 (2002).

Rao KS, Mishra SH. Hepatopotective activity of whole plant of Fumaria indica. Indian Pharm Sci 1997; 59: 165.

20Pandey MB, Singh AK, Singh AK, Singh UP. Inhibitive effect of fuyuziphine isolated from plant (Pittapapra) (Fumaria indica) on spore germination of some fungi. Mycobiology 2007; 35(3): 157-158.

Habibi Tirtash F, Keshavarzi M, Fazeli F. Antioxidant components of Fumaria species. World academy of sciences, Engineering and Technology 2011; 74: 238-241.

K.M. Nandkarni 1982(& A.K. Nandkarni) Indian Metria Medica, Bombay Popular Prakashan 1982, Vol-1 pp. 1205-1206

Suchalatha S., Devi C.S. Anti-oxidant activity of ethanolic extract of Terminalia chebula fruit against isoproterenol induced oxidative stress in rats. Ind J Biochem Biophy 2005; 42:246-9.

Said Muhammad, Barkat Ali Khan, Naveed Akhtar, Tariq Mahmood, Akhtar Rasul, Irshad Hussain, Haroon Khan and Amir Badshah. The morphology, extractions, chemical constituents and uses of Terminalia chebula: A review: Journal of Medicinal Plants Research 2012; 6(33):4.

Shinde S.L., More S.M., Junne S.B., Wadje S.S. The antifungal activity of five Terminalia species checked by paper disk method. International Journal of Pharma Res and Develop 2011; 3(2):5.

Lin L.T., Chen T.Y., Chung C.Y., Noyce R.S., T.B. Grindley, McCormick C., Lin T.C., Wang G.H., Lin C.C., Richardson C.D. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread. Journal of Virol. 2011; 85(9):5.

Suchalatha S, Shyamadevi CS. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Indian J Exp Biol 2004; 42(2): 174-178.

Orhan _IE, Ozcelik B, Kartal M, Kan Y. Antimicrobial and antiviral effects of essential oils from selected Umbelliferae and Labiatae plants and individual essential oil components. Turk J Biol. 2012;36:239e246.

Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Res. 2010;9:163.

Boskabady M, Kiani S, Rakhshandah H. Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism (s). J Ethnopharmacol. 2006;106:377e382.

K.M. Nandkarni (& A.K. Nandkarni) Indian Metria Medica, Bombay Popular Prakashan 1982, Vol-1 pp. 284, 286-288

K.M. Nandkarni (& A.K. Nandkarni) Indian Metria Medica, Bombay Popular Prakashan 1982, Vol-1 pp. 284, 286-288

Anonymous Liver Tox: Clinical and Research Information on Drug Induced Liver Injury [Intenet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases;2012-Senna. [ Updated 2020Apr 1].

Mustafa Oskey and Dilek Sari “Antimicrobial Screening of Some Turkish Medicinal Plants” Pharmaceutical Biology 2007, Vol. 45, No. 3, pp. 176–181

Cai YJ, Fang JG, Ma LP, Yang L, Liu ZL: Inhibition of freeradical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochim Biophys Acta 2003;1637:31–38.

Craig WJ: Phytochemicals: guardians of our health. J Am Diet Assoc 1997;97(10 Suppl 2):S199–S204.

Das S, Das DK: Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets 2007;6:168–173


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